Genes, tecido adiposo, inflamação, hormônios e biomarcadores. 145 artigos nesta área.
Lipedema is a chronic disorder that affects the subcutaneous adipose tissue of the lower and upper limbs and results in painful fat accumulations. During the reproductive life span, about 11% of women are affected; however, there…
Lüchinger JE et al. · Archives of gynecology and obstetrics · 23 jan 2026
Background: Lipedema is a progressive disorder of subcutaneous connective tissue, predominantly affecting women, and characterized by an increase in subcutaneous adipose tissue, particularly in the lower body. This study aims to…
Di Renzo L et al. · Nutrients · 13 dez 2025
Lipedema is a chronic, progressive disorder marked by the abnormal accumulation of subcutaneous adipose tissue, predominantly in the lower body and almost exclusively affecting women. In recent years, the off-label use of…
Amato AC, Amato JS, Benitti D · Cureus · 19 nov 2025
Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant…
Cifarelli V · Obesity reviews : an official journal of the International Association for the Study of Obesity · 27 mai 2025
Lipoedema is a symmetrically localised, painful hypertrophy of subcutaneous adipose tissue in the extremities with marked disproportion to the trunk, and almost exclusively affects females. Despite being first described over 80…
Funke S et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 20 nov 2023
Regenerative therapies like cell-assisted lipotransfer or preclinical experimental studies use adipose tissue-derived stem cells (ASCs) as the main therapeutic agent. But there are also factors depending on the clinical donor…
Kuhlmann C et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 8 dez 2020
The aim of this study was to characterize global scientific output on lipedema from 2000 to 2025 and identify emerging thematic trends, with emphasis on the emergence of immunological research. Publications indexed in Google…
Amato ACM, Amato JLS, Benitti DA · Revista da Associacao Medica Brasileira (1992) · 16 out 2026
Aim: This narrative review summarises evidence on pathogenetic mechanisms of adipose tissue remodelling and adipokine dysregulation in lipedema, focusing on adipocyte hypertrophy and hyperplasia, fibrosis, microcirculatory and…
Sierawska O, Dudzińska W · Current issues in molecular biology · 7 out 2026
Lipedema is a chronic, predominantly female disorder characterized by disproportionate regional expansion of subcutaneous adipose tissue, pain, tenderness, and easy bruising. Reported abnormalities involve adipocytes,…
Faulhaber J et al. · Cells · 7 out 2026
A progressive disease, lipedema is characterized by bilaterally symmetrical and disproportional accumulation of subcutaneous adipose tissue (SAT) in the extremities, leading to severe pain, inflammation, and mobility issues.…
Gohlke S et al. · Frontiers in cell and developmental biology · 1 out 2026
The aim of this study was to compare serum adiponectin, leptin, resistin, irisin, and galectin-3 levels between patients with lipedema and healthy controls, and to examine their relationship with subcutaneous adipose tissue…
Şahingöz Bakırcı E, Demir Karakılıç G, Kaymak E · Aesthetic plastic surgery · 28 set 2026
The clinical course of lipedema in women receiving hormonal treatment for concomitant estrogen-dependent gynecological disorders remains insufficiently characterized. This study aimed to describe gynecological and…
Frederichi de Souza P · Cureus · 24 set 2026
BackgroundLipedema is a frequently misdiagnosed chronic condition that significantly impacts patients' quality of life. As artificial intelligence (AI)-based large language models (LLMs) become increasingly integrated into…
Sanır R et al. · Phlebology · 23 set 2026
The Questionário de avaliação sintomática do lipedema (QuASiL - Lipedema Symptom Assessment Questionnaire) assesses 13 distinct inflammatory symptoms of lipedema, but whether these symptoms resolve and recur simultaneously or…
Amato ACM, Amato JLS, Benitti DA · Jornal vascular brasileiro · 7 set 2026
Lipedema is a common, female-predominant disorder characterized by disproportionate, painful lower-limb adipose tissue, and it still lacks an objective biomarker, a disease-modifying therapy, or consensus on whether its core…
Amato AC, Amato JL, Benitti D · Cureus · 1 set 2026
Lipedema and obesity are often misdiagnosed or clinically confused yet arise via distinct mechanisms, complicating diagnosis and treatment. This review synthesizes evidence differentiating these conditions across genetic,…
Güney YE, Demiralay SÇ, Keser İ · Current issues in molecular biology · 1 set 2026
Lipedema is a chronic disorder of subcutaneous adipose tissue characterized by disproportionate fat accumulation, pain, and progressive functional impairment, predominantly affecting women. Research remains fragmented across…
Viana DPdC, Invitti AL, Schor E · Frontiers in cell and developmental biology · 22 jul 2026
Lipedema is a chronic inflammatory disorder of adipose tissue that predominantly affects women and is characterized by disproportionate subcutaneous fat accumulation, pain, spontaneous bruising, and significantly impaired quality…
Lima MF · Jornal vascular brasileiro · 20 jul 2026
Lipedema is a chronic disorder that predominantly affects women and is characterized by abnormal subcutaneous adipose tissue accumulation, pain, and vascular dysfunction. However, reliable circulating biomarkers that reflect…
Kempa S et al. · Diseases (Basel, Switzerland) · 12 jul 2026
Background: Endometriosis and lipedema are chronic female-predominant disorders characterized by persistent pain that is frequently disproportionate to anatomical lesion burden. Although traditionally interpreted within distinct…
Viana DPdC et al. · Biomedicines · 3 jul 2026
ObjectivesGenerative artificial intelligence (AI) models capable of producing photorealistic medical images are increasingly proposed for patient education, clinical illustration, and trainee instruction. However, their ability…
Özbek IC et al. · Phlebology · 2 jul 2026
Lipedema is a chronic disorder characterized by disproportionate subcutaneous fat accumulation and pain, with an incompletely understood inflammatory component. It remains unclear whether this inflammatory profile is…
Şahingöz Bakırcı E, Demir Karakılıç G · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 30 jun 2026
Lipedema is a chronic adipose tissue disorder characterised by disproportionate accumulation of subcutaneous fat within specific anatomical depots, most commonly the lower extremities, with relative sparing of the trunk. Despite…
Reid I et al. · Frontiers in cell and developmental biology · 17 jun 2026
BACKGROUND/AIM: Although various distinctive morphological features such as hyperproliferation of adipocytes, fibrosis, and inflammation have been described in the progression of lipedema, the underlying mechanisms of these…
Cagliyan Turk A, Erden E, Borman P · Lymphatic research and biology · 9 jun 2026
Lipedema is a chronic adipose tissue disorder predominantly affecting women, often misdiagnosed as obesity or lymphedema. Emerging evidence points to microvascular dysfunction and chronic inflammation in its pathophysiology. This…
Yavas AD · Neuro endocrinology letters · 28 mai 2026
Sem abstract disponível no PubMed.
Hanke CW · Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 18 mai 2026
Lipedema is a chronic, multifactorial disorder characterized by connective tissue dysregulation, in which vascular dysfunction plays a significant role. Lipedema manifests as symmetrical, painful accumulation of adipose tissue,…
Al-Ghadban S et al. · Frontiers in cell and developmental biology · 8 mai 2026
Lipedema, a painful disease that almost exclusively affects women, leads to an excessive accumulation of subcutaneous adipose tissue, primarily in the extremities. Morphologically, it is characterized by hyperplasia and…
Steiner M et al. · Frontiers in cell and developmental biology · 1 mai 2026
Background/Objectives: Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, microvascular dysfunction, and low-grade inflammation. Although low-carbohydrate, high-fat (LCHF)…
Chachaj A et al. · Nutrients · 28 abr 2026
Lipedema is a chronic and often debilitating adipose tissue disorder that primarily affects women. The disease is characterized by disproportionate and symmetrical accumulation of subcutaneous fat in the extremities. Despite the…
Soni K, Abbott RD · Frontiers in cell and developmental biology · 21 abr 2026
Lipedema is a chronic, female-predominant disorder of subcutaneous adipose tissue characterized by disproportionate fat expansion, pain, and fibrosis. Despite its high prevalence, the cellular mechanisms underlying lipedema…
Morawitz KH, Gross JC · Frontiers in cell and developmental biology · 31 mar 2026
Lipedema is a chronic, progressive adipose tissue disorder characterized by disproportionate subcutaneous fat accumulation, pain, edema, and resistance to conventional weight-loss strategies. Although traditionally conceptualized…
Viana DPdC, Invitti AL, Schor E · International journal of molecular sciences · 1 mar 2026
lipedema is a chronic, progressive adipose disorder predominantly affecting women, characterized by painful, symmetrical subcutaneous fat accumulation, and typically resistant to lifestyle interventions. The pathophysiology of…
Santella B et al. · Journal of translational medicine · 24 jan 2026
Lipedema is a chronic disorder that affects the subcutaneous adipose tissue of the lower and upper limbs and results in painful fat accumulations. During the reproductive life span, about 11% of women are affected; however, there…
Lüchinger JE et al. · Archives of gynecology and obstetrics · 23 jan 2026
Lipedema is a chronic disease characterized by the symmetrical accumulation of adipose tissue in the lower body, primarily affecting women. Despite being recognized for over 85 years, the pathophysiology, diagnosis, and treatment…
Faria AM et al. · npj metabolic health and disease · 17 jan 2026
Lipedema is a chronic and progressive disorder characterized by disproportionate fat accumulation, mainly affecting the lower extremities of women, and commonly accompanied by sensations of heaviness, tenderness, and discomfort.…
Dal'Forno-Dini T et al. · Anais brasileiros de dermatologia · 8 jan 2026
Background: Emerging evidence suggests that lipedema may share hormonal, inflammatory, and genetic mechanisms with gynecologic diseases, particularly endometriosis. However, the extent and nature of these interrelationships…
Viana DPdC, Invitti AL, Schor E · Biomedicines · 7 jan 2026
Sem abstract disponível no PubMed.
Funcke J, Scherer PE, Straub LG · Trends in molecular medicine · 16 dez 2025
Lipedema is a chronic, progressive adipose tissue disorder that predominantly affects women and is characterized by disproportionate fat accumulation, pain, and edema. Hormonal fluctuations are frequently reported as triggers or…
Amato AC, Amato JL, Benitti D · Cureus · 14 dez 2025
Background: Lipedema is a progressive disorder of subcutaneous connective tissue, predominantly affecting women, and characterized by an increase in subcutaneous adipose tissue, particularly in the lower body. This study aims to…
Di Renzo L et al. · Nutrients · 13 dez 2025
BACKGROUND/OBJECTIVES: Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, and low-grade systemic inflammation, primarily affecting women. This study investigated the…
Tel Adıgüzel K et al. · International journal of obesity (2005) · 27 nov 2025
Lipedema is a chronic, progressive disorder marked by the abnormal accumulation of subcutaneous adipose tissue, predominantly in the lower body and almost exclusively affecting women. In recent years, the off-label use of…
Amato AC, Amato JS, Benitti D · Cureus · 19 nov 2025
Obesity is increasingly recognized not only as a metabolic disorder, but also as a state of chronic low-grade inflammation that predisposes to systemic complications. Within this context, Dercum's disease (DD), or adiposis…
Reytor-González C et al. · International journal of molecular sciences · 18 nov 2025
Lipedema is a chronic disorder characterized by the symmetrical accumulation of subcutaneous adipose tissue, predominantly affecting women. Despite increasing recognition, the pathophysiological mechanisms underlying adipose…
Rabiee A · Frontiers in cell and developmental biology · 6 nov 2025
Lipedema is a chronic, progressive adipose tissue disorder that affects up to 10% of women and is characterized by disproportionate lower-limb fat accumulation, pain, edema, and resistance to conventional weight-loss approaches.…
Viana DPdC, Invitti AL, Schor E · International journal of molecular sciences · 5 nov 2025
Knee pain in women with lipedema is frequently misattributed and undertreated. We outline a biomechanical and inflammatory cascade linking systemic adipose dysfunction, anabolic resistance, and thigh-predominant sarcopenia to…
Amato AC · Cureus · 24 out 2025
Lipedema is a clinical entity that deserves special attention, as it predominantly affects women during specific hormonal phases such as menarche, pregnancy and menopause. Among the available treatments, surgery is considered the…
Parizotto NA et al. · Lasers in medical science · 15 out 2025
Background/Objectives: Lipedema is a chronic, progressive disorder of the adipo-fascial tissue characterized by abnormal subcutaneous fat accumulation, inflammation, fibrosis, pain, and edema. Despite its considerable impact on…
Fiengo E, Sbarbati A · Journal of clinical medicine · 12 out 2025
Lipedema is a chronic disorder characterized by symmetrical and disproportionate fat accumulation, pain, and easy bruising, often resistant to conventional treatments. Functional dysmetria (FD), a maladaptive neuromotor response…
Fontani V et al. · Cureus · 14 set 2025
Estrogen-dependent conditions, such as endometriosis, adenomyosis, lipedema, polycystic ovary syndrome, and breast cancer, are intimately involved with hormonal changes related to estrogen and their receptors. These conditions…
Renke G et al. · Current issues in molecular biology · 27 ago 2025
Lipedema, characterized by the disproportionate accumulation of fat in the lower extremities, pain, and tenderness, is frequently misdiagnosed and underestimated. This evolutionary perspective reframes lipedema as an ancestral…
Amato AC · Cureus · 26 jul 2025
Lipedema is a chronic, estrogen-sensitive adipose tissue disorder characterized by disproportionate subcutaneous fat accumulation, fibrosis, inflammation, and resistance to fat mobilization. Despite its high prevalence, lipedema…
Pinto da Costa Viana D, Caseri Câmara L, Borges Palau R · International journal of molecular sciences · 23 jul 2025
Lipoedema is a disease that affects women and is characterised by an abnormal accumulation of fatty tissue, with pain and a feeling of heaviness in the lower limbs. Approximately 30 % of patients also have involvement of the…
Ekerhovd IW et al. · Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 23 jun 2025
Lipedema is a chronic and progressive disease that predominantly affects women, characterized by a disproportionate increase in subcutaneous adipose tissue (AT), particularly in the lower limbs. It is associated with significant…
Cifarelli V · Obesity reviews : an official journal of the International Association for the Study of Obesity · 27 mai 2025
Lipedema is a chronic disease in females characterized by pathologic subcutaneous adipose tissue expansion and hitherto remains without druggable targets. In this observational study, we investigated the molecular hallmarks of…
Straub LG et al. · Metabolism: clinical and experimental · 15 mar 2025
This study aimed to evaluate adipose tissue of lipedema patients. Gluteo-femoral (affected area) and interscapular (nonaffected area) adipose tissue from 10 lean patients affected by lipedema stage 1 to 2 was studied and compared…
Michelini S et al. · Obesity (Silver Spring, Md.) · 12 mar 2025
Sem abstract disponível no PubMed.
Allerton TD · Obesity (Silver Spring, Md.) · 10 mar 2025
Lipedema is a lipodystrophic disease that is typically characterized by a marked increase in lower-body subcutaneous adipose tissue that is purported to have increased inflammation and fibrosis, have impaired…
Cifarelli V et al. · Diabetes · 1 mar 2025
Background/Objectives: Lipedema is a progressive disease that results in the bilateral and symmetrical accumulation of subcutaneous fat in the legs and/or arms, affecting almost exclusively women. Methods: A comprehensive review…
Grewal T, Kempa S, Buechler C · Biomedicines · 23 fev 2025
Purpose: The study's main objective was to assess the efficacy and safety of TANIT, a platform combining functional dermal stimulation with damped bioactive current and mechanical stimulation to reduce adipose tissue (AT) in…
Casart Quintero YC et al. · Photobiomodulation, photomedicine, and laser surgery · 7 fev 2025
Lipedema is characterized by abnormal fat deposition in areas such as the arms, hips, buttocks, and thighs, sparing the hands and feet. Symptoms include pain, bruising, edema, and subcutaneous nodules, which resist traditional…
Kamamoto F et al. · Jornal vascular brasileiro · 20 jan 2025
Diseases affecting adipose tissue (AT) function include obesity, lipodystrophy, and lipedema, among others. Both a lack of and excess AT are associated with increased risk for developing diseases including type 2 diabetes…
Blüher M · Journal of obesity & metabolic syndrome · 30 dez 2024
Lipedema is a disease typically affecting women with a symmetrical, painful fat distribution disorder, which is hypothesized to be caused by impaired adipogenesis, inflammation, and extracellular matrix remodeling, leading to…
Streubel MK et al. · Plastic and reconstructive surgery. Global open · 8 nov 2024
Lipedematous scalp (LS) and lipedematous alopecia (LA) are uncommon conditions with an unclear cause. Over the past century, about 115 cases have been documented in the literature. It is unknown if these disorders are indeed so…
Koç Yıldırım S · Archives of dermatological research · 26 out 2024
Lipedema is a chronic disorder affecting women with a 10% incidence worldwide. It is often confused with obesity. This study was undertaken to study microRNAs in lipedema tissue assessed by direct hybridization using the robust…
Cione E et al. · Current issues in molecular biology · 25 out 2024
Gestrinone (R-2323), or ethylnorgestrienone, is a synthetic steroid of the 19-nortestosterone group more commonly used as an oral, intravaginal, or subcutaneous implant for the treatment of endometriosis, contraception, and…
Renke G et al. · Pharmaceuticals (Basel, Switzerland) · 22 set 2024
Background: Despite its increasing incidence and prevalence throughout Western countries, lipedema continues to be a very enigmatic disease, often misunderstood or misdiagnosed by the medical community and with an intrinsic…
Pagani A et al. · Cells · 13 jun 2024
Lipomatoses are benign proliferation of adipose tissue. Lipomas (benign fat tumors) are the most common component of lipomatosis. They may be unique or multiple, encapsulated or not, subcutaneous or sometimes visceral. In some…
Dupuis H et al. · Annales d'endocrinologie · 12 jun 2024
TRPV4 channels are critical regulators of blood vascular function and have been shown to be dysregulated in many disease conditions in association with inflammation and tissue fibrosis. These are key features in the…
Schulz ME et al. · bioRxiv : the preprint server for biology · 23 mai 2024
Lipedema is a chronic, idiopathic, and painful disease characterized by an excess of adipose tissue in the extremities. The goal of this study is to characterize the gene expression of estrogen receptors (ERα and ERβ), G…
Al-Ghadban S et al. · Biomedicines · 9 mai 2024
Lipedema is a poorly understood disorder of adipose tissue characterized by abnormal but symmetrical deposition of subcutaneous white adipose tissue (WAT) in proximal extremities. Here, we propose that the underlying cause for…
Kruglikov IL, Scherer PE · Trends in endocrinology and metabolism: TEM · 29 abr 2024
Correction to: Eur Rev Med Pharmacol Sci 2023; 27 (6 Suppl): 127-136-DOI: 10.26355/eurrev_202312_34697 After publication and following some post-publication concerns, the authors have applied the following corrections to the…
Kaftalli J et al. · European review for medical and pharmacological sciences · 1 mar 2024
Background: Lipedema is a progressive condition involving excessive deposition of subcutaneous adipose tissue, predominantly in the lower limbs, which severely compromises quality of life. Despite the impact of lipedema, its…
Morgan S et al. · Lymphatic research and biology · 26 fev 2024
The Editor in Chief and the Publisher are issuing an expression of concern to alert readers to the fact that the Special Issue titled "Omics sciences in the personalization of diagnosis and therapy" and, in particular, the…
Listed NA · European review for medical and pharmacological sciences · 1 jan 2024
Lipedema is an autosomal dominant genetic disease that mainly affects women. It is characterized by excess deposition of subcutaneous adipose tissue, pain, and anxiety. The genetic and environmental etiology of lipedema is still…
Kaftalli J et al. · European review for medical and pharmacological sciences · 1 dez 2023
Lipedema is a debilitating chronic condition predominantly affecting women, characterized by the abnormal accumulation of fat in a symmetrical, bilateral pattern in the extremities, often coinciding with hormonal imbalances.…
Kaftalli J et al. · European review for medical and pharmacological sciences · 1 dez 2023
Lipoedema is a symmetrically localised, painful hypertrophy of subcutaneous adipose tissue in the extremities with marked disproportion to the trunk, and almost exclusively affects females. Despite being first described over 80…
Funke S et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 20 nov 2023
Lipedema is a chronic disorder that mainly affects women. It is often misdiagnosed, and its etiology remains unknown. Recent research indicates an accumulation of macrophages and a shift in macrophage polarization in lipedema.…
Vasella M et al. · Metabolites · 23 out 2023
Lipedema is a connective tissue disorder characterized by increased dilated blood vessels (angiogenesis), inflammation, and fibrosis of the subcutaneous adipose tissue. This project aims to gain insights into the angiogenic…
Al-Ghadban S et al. · International journal of molecular sciences · 1 set 2023
Lipoedema is an adipose tissue disorder that is still not fully understood. The primary purpose of this study is to explore the state of knowledge and understanding of lipoedema among Polish women. The secondary aim is to…
Hansdorfer-Korzon R et al. · BMC women's health · 29 ago 2023
Lipedema is a painful subcutaneous adipose tissue (SAT) disease characterized by adipocyte hypertrophy, immune cell recruitment, and fibrosis in the affected areas. These features are thought to contribute to the development and…
Kruppa P et al. · Frontiers in immunology · 28 jul 2023
Pain, which is a central characteristic of lipedema, allows differentiation from other fat tissue diseases. The analysis of the multiple aspects of pain beyond a quantification of pain scale scores could make molecular disease…
Hucho T · Dermatologie (Heidelberg, Germany) · 12 jul 2023
Lipedema, lipohypertrophy and secondary lymphedema are three conditions characterized by disproportionate subcutaneous fat accumulation affecting the extremities. Despite the apparent similarities and differences among their…
von Atzigen J et al. · International journal of molecular sciences · 20 abr 2023
Sem abstract disponível no PubMed.
Crescenzi R et al. · Journal of magnetic resonance imaging : JMRI · 6 abr 2023
Sem abstract disponível no PubMed.
Baklacı M, Eyigör S · Journal of magnetic resonance imaging : JMRI · 31 mar 2023
Lipedema, diagnosed most often in women, is a progressive disease characterized by the disproportionate and symmetrical distribution of adipose tissue, primarily in the extremities. Although numerous results from in vitro and in…
Ernst AM et al. · Plastic and reconstructive surgery · 14 mar 2023
This study examines the role of MTHFR gene polymorphism (rs1801133) in women with lipedema (LIPPY) body composition parameters compared to a control group (CTRL). We carried out a study on a sample of 45 LIPPY and 50 women as a…
Gualtieri P et al. · European review for medical and pharmacological sciences · 1 fev 2023
Mast cells are immune cells that mediate hypersensi-tivity and allergic reactions in the body, secreting histamine and other inflammatory molecules. They have been associated with different inflammatory conditions such as obesity…
Bonetti G et al. · La Clinica terapeutica · 1 jan 2023
Lipedema, a complex and enigmatic adipose tissue disorder, remains poorly understood despite its significant impact on the patients' quality of life. Genetic investigations have uncovered potential contributors to its…
Bonetti G et al. · La Clinica terapeutica · 1 jan 2023
When studying the current literature, one might get the impression that lipedema is a "modern" disease, with increasing incidence and augmenting prevalence throughout Western countries during the last decade. However, a quick…
Ernst AM et al. · Journal of personalized medicine · 31 dez 2022
Lipedema is a chronic and progressive adipose tissue disorder, characterized by the painful and disproportionate increase of the subcutaneous fat in the lower and/or upper extremities. While distinct immune cell infiltration is a…
Wolf S et al. · Frontiers in immunology · 20 dez 2022
Lipedema is an adipofascial disorder that almost exclusively affects women. Lipedema leads to chronic pain, swelling, and other discomforts due to the bilateral and asymmetrical expansion of subcutaneous adipose tissue. Although…
Poojari A, Dev K, Rabiee A · Biomedicines · 30 nov 2022
Lipedema is a common disorder characterized by excessive deposition of subcutaneous adipose tissue (SAT) in the legs, hips, and buttocks, mainly occurring in adult women. Although it appears to be heritable, no specific genes…
Klimentidis YC et al. · European journal of human genetics : EJHG · 16 nov 2022
Lipedema may be considered a model for healthy expandability of subcutaneous adipose tissue (SAT). This condition is characterized by the disproportional and symmetrical SAT accumulation in the lower-body parts and extremities,…
Nankam PAN et al. · Frontiers in endocrinology · 31 out 2022
The most relevant hallmarks of cellulite include a massive protrusion of superficial adipose tissue into the dermis, reduced expression of the extracellular glycoprotein fibulin-3, and an unusually high presence of MUSE cells in…
Kruglikov IL, Scherer PE · Obesity reviews : an official journal of the International Association for the Study of Obesity · 26 out 2022
Lipoedema is a chronic adipose tissue disorder mainly affecting women, causing excess subcutaneous fat deposition on the lower limbs with pain and tenderness. There is often a family history of lipoedema, suggesting a genetic…
Grigoriadis D et al. · PloS one · 13 out 2022
Lipedema is a disease with abnormally increased adipose tissue deposition and distribution. Pain sensations have been described in the clinical evaluation of lipedema, but its etiology remains poorly understood. We hypothesized…
Chakraborty A et al. · International journal of molecular sciences · 7 set 2022
Lymphedema and lipedema are complex diseases. While the external presentation of swollen legs in lower-extremity lymphedema and lipedema appear similar, current mechanistic understandings of these diseases indicate unique aspects…
Duhon BH et al. · International journal of molecular sciences · 14 jun 2022
Lipedema is a chronic, progressive disease of adipose tissue with unknown etiology. Based on the relevance of the stromal vascular fraction (SVF) cell population in lipedema, we performed a thorough characterization of…
Strohmeier K et al. · Biomedicines · 18 mai 2022
Lipedema is a multifaceted chronic fat disorder characterized by the bilateral and disproportionate accumulation of fat predominantly in the lower body regions of females. Research strongly supports that estrogen factors likely…
Hill JL et al. · Methods and protocols · 15 abr 2022
Lipedema is a disabling disease characterized by symmetric enlargement of the lower and/or upper limbs due to deposits of subcutaneous fat, that is easily misdiagnosed. Lipedema can be primary or syndromic, and can be the main…
Michelini S et al. · Journal of personalized medicine · 11 fev 2022
Adipose tissue, once thought to be an inert receptacle for energy storage, is now recognized as a complex tissue with multiple resident cell populations that actively collaborate in response to diverse local and systemic…
Westcott GP, Rosen ED · Endocrinology · 1 jan 2022
Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is often mistaken for obesity and causes significant impairment to mobility and quality-of-life. To identify molecular mechanisms underpinning lipedema,…
Ishaq M et al. · International journal of obesity (2005) · 11 nov 2021
Lipedema is a painful fat disorder that affects ~11% of the female population. It is characterized by bilateral, disproportionate accumulation of subcutaneous adipose tissue predominantly in the lower body. The onset of lipedema…
Katzer K et al. · International journal of molecular sciences · 29 out 2021
Lipedema is an adipose tissue disorder characterized by the disproportionate increase of subcutaneous fat tissue in the lower and/or upper extremities. The underlying pathomechanism remains unclear and no molecular biomarkers to…
Wolf S et al. · International journal of molecular sciences · 24 mar 2021
Williams syndrome is a multisystem disorder caused by a microdeletion on chromosome 7q. Throughout infancy, childhood, and adulthood, abnormalities in body composition and in multiple endocrine axes may arise for individuals with…
Stanley TL, Leong A, Pober BR · Current opinion in endocrinology, diabetes, and obesity · 1 fev 2021
Regenerative therapies like cell-assisted lipotransfer or preclinical experimental studies use adipose tissue-derived stem cells (ASCs) as the main therapeutic agent. But there are also factors depending on the clinical donor…
Kuhlmann C et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 8 dez 2020
In recent years, crowdfunding for medical expenses has gained popularity, especially in countries without universal health coverage. Nevertheless, universal coverage does not imply covering all medical costs for everyone. In…
Lublóy Á · BMC public health · 9 nov 2020
The growth and differentiation of adipose tissue-derived stem cells (ASCs) is stimulated and regulated by the adipose tissue (AT) microenvironment. In lipedema, both inflammation and hypoxia influence the expansion and…
Al-Ghadban S et al. · International journal of molecular sciences · 7 nov 2020
Description Adipose tissue (AT) has diverse and important functions in body insulation, mechanical protection, energy metabolism and the endocrine system. Despite its relative abundance in the human body, the clinical…
Lee SW, Van Dien C, Won SJ · HCA healthcare journal of medicine · 29 out 2020
Lipedema is a painful, underdiagnosed adipose tissue disorder, characterized by symmetrical swelling of the extremities due to subcutaneous fat deposition in the buttocks, thighs, legs, and arms, sparing the most distal part of…
Aksoy H, Karadag AS, Wollina U · Dermatologic therapy · 12 out 2020
Lipedema is an often underdiagnosed chronic disorder that affects subcutaneous adipose tissue almost exclusively in women, which leads to disproportionate fat accumulation in the lower and upper body extremities. Common…
Michelini S et al. · International journal of molecular sciences · 29 ago 2020
Lipoedema is associated with widespread adipose tissue expansion, particularly in the proximal extremities. The mechanisms that drive the development of lipoedema are unclear. In this Perspective article, we propose a new model…
Kruglikov IL, Joffin N, Scherer PE · Nature reviews. Endocrinology · 13 ago 2020
Genetic or acquired defects of the lymphatic vasculature often result in disfiguring, disabling, and, occasionally, life-threatening clinical consequences. Advanced forms of lymphedema are readily diagnosed clinically, but more…
Ma W et al. · JCI insight · 9 jul 2020
Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and is commonly misdiagnosed as lymphedema or obesity. The molecular determinants of the lipedema remain largely…
Felmerer G et al. · Scientific reports · 2 jul 2020
Lipedema is a common adipose tissue disorder affecting women, characterized by a symmetric subcutaneous adipose tissue deposition, particularly of the lower extremities. Lipedema is usually underdiagnosed, thus remaining an…
Felmerer G et al. · The Journal of surgical research · 11 mai 2020
Lipedema is a chronic, progressive disease of adipose tissue with lack of consistent diagnostic criteria. The aim of this study was a thorough comparative characterization of extracellular microRNAs (miRNAs) from the stromal…
Priglinger E et al. · Scientific reports · 29 abr 2020
Lipedema is a disorder of adipose tissue characterized by abnormal subcutaneous fat deposition, leading to swelling and enlargement of the lower limbs and trunk. The aim of this study was to evaluate the lipedema phenotype by…
Di Renzo L et al. · European review for medical and pharmacological sciences · 1 mar 2020
Lipedema is a painful loose connective tissue disorder characterized by a bilaterally symmetrical fat deposition in the lower extremities. The goal of this study was to characterize the adipose-derived stem cells (ASCs) of…
Al-Ghadban S et al. · Cells · 12 fev 2020
Obesity is a leading cause of cardiovascular diseases and cancer. Body mass is regulated by the balance between energy uptake and energy expenditure. The etiology of obesity is determined by multiple factors including genetics,…
Ho Y, Srinivasan RS · Frontiers in physiology · 22 jan 2020
Syndromes with localized accumulation of subcutaneous fatty tissue belong to a group of genetically and phenotypically heterogeneous disorders. These diseases may show some common signs, such as nodular fat, symmetrical fat…
Precone V et al. · Acta bio-medica : Atenei Parmensis · 30 set 2019
Lipedema is characterized by localized accumulation of fat in the extremities, which is typically unresponsive to dietary regimens or physical activity. Although the disease is well described and has a high incidence, little is…
Bauer A et al. · Plastic and reconstructive surgery · 1 set 2019
The aim of this qualitative review is to provide an update on the current understanding of the genetic determinants of lipedema and to develop a genetic test to differentiate lipedema from other diagnoses. An electronic search…
Paolacci S et al. · European review for medical and pharmacological sciences · 1 jul 2019
Lipedema is a common painful SAT disorder characterized by enlargement of fat primarily in the legs of women. Case reports of lipedema tissue samples demonstrate fluid and fibrosis in the interstitial matrix, increased…
Al-Ghadban S et al. · Journal of obesity · 3 mar 2019
A 66-year-old African woman suffered from a boggy thickening of the scalp in the frontoparietal area and the vertex accompanied by headache since infancy. In her thirties, she developed diffuse hair loss in the same area.…
Accaputo O et al. · Case reports in dermatology · 23 jan 2019
Lipoedema is a painful, chronic progressive disorder of adipose tissue, characterised by symmetrical swelling of the lower and/or upper limbs. Due to a lack of awareness, lipoedema is frequently misdiagnosed. However, accurate…
Wiedner M, Aghajanzadeh D, Richter DF · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 8 jan 2019
Lipoedematous scalp (LS) is an extremely rare condition characterised by a soft and boggy consistency in the scalp due to an increased layer of subcutaneous tissue.In this report, we present a case of LS in a 64-year-old Indian…
Law S, Jayarajan R · BMJ case reports · 9 out 2017
Background Lipedema is a common painful subcutaneous adipose tissue (SAT) disorder in women affecting the limbs. SAT therapy is a manual therapy to improve soft tissue quality. Objective Determine if SAT therapy improves pain and…
Herbst KL, Ussery C, Eekema A · Hormone molecular biology and clinical investigation · 20 set 2017
Sem abstract disponível no PubMed.
Koyama H, Tanaka T, Imaeda K · BMJ case reports · 23 ago 2017
Lipedema is a hormone-related disease of women characterized by enlargement of the extremities caused by subcutaneous deposition of adipose tissue. In healthy patients application of autologous adipose tissue-derived cells has…
Priglinger E et al. · Cytotherapy · 25 abr 2017
Sem abstract disponível no PubMed.
Cooper G · British journal of community nursing · 2 jan 2017
Lipedema, or adiposis dolorosa, is a common adipose tissue disorder that is believed to affect nearly 11% of adult women worldwide. It is characterized most commonly by disproportionate adipocyte hypertrophy of the lower…
Buck DW, Herbst KL · Plastic and reconstructive surgery. Global open · 28 set 2016
Lipedema is a chronic disorder characterized by abnormal distribution of subcutaneous adipose tissue on the proximal extremities, pain and capillary fragility. Its etiology is unknown but in analogy to central obesity, chronic…
Schneble N, Wetzker R, Wollina U · Journal of biological regulators and homeostatic agents · 1 jan 2016
Sem abstract disponível no PubMed.
Bundrick JB, Litin SC · Disease-a-month : DM · 1 ago 2015
Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females. There are many debates regarding the diagnosis as well as the treatment strategies of the disease. The…
Szél E et al. · Medical hypotheses · 23 ago 2014
Bone morphogenetic proteins (BMPs) induce osteogenesis, making them useful for decreasing time to union and increasing union rates. Although the advantages of BMP-2 as a substitute for iliac crest graft have been elucidated, less…
Merrick MT, Hamilton KD, Russo SS · The spine journal : official journal of the North American Spine Society · 22 jun 2013
Lipedema is a disproportional obesity due to unknown pathomechanism. Its major hallmark is frequent hematoma formation related to increased capillary fragility and reduced venoarterial reflex. Beyond microangiopathy, both venous…
Szolnoky G et al. · Lymphology · 1 jun 2012
Lipedema is a disease with unknown etiology presenting as bilateral and symmetric enlargement of the lower extremities due to subcutaneous deposition of the adipose tissue. Here we describe the histopathological features of the…
Suga H et al. · Journal of cutaneous pathology · 1 dez 2009
A 23-year-old male was referred to our clinic with diagnosis of idiopathic isolated growth hormone deficiency. A detailed family history revealed short stature and swelling of legs which only affected females in four generations…
Bano G et al. · Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 16 jul 2009
We report a familial Sotos syndrome in two children, boy and girl, aged 17 and 8 years, and in their 44 year old mother, who displayed normal intelligence at adult age, but suffered from insulin dependent diabetes mellitus,…
Zechner U et al. · European journal of medical genetics · 21 jun 2009
Sem abstract disponível no PubMed.
El Darouti MA et al. · European journal of dermatology : EJD · 1 jun 2007
Only a limited number of studies on cellulite have been published in the international literature and many of them reach somewhat antithetical conclusions. Consequently, it is not yet possible to reconcile the extreme differences…
Terranova F, Berardesca E, Maibach H · International journal of cosmetic science · 1 jun 2006
In vivo measurements in 26 female patients with lipedema and cellulite parameters were carried out before and after therapy by means of complex physical decongestive therapy (CPDT) including manual lymph drainage and compression…
Siems W et al. · BioFactors (Oxford, England) · 1 jan 2005
Lipedema is a condition characterized by diffuse, bilaterally symmetrical, painful swelling of the legs and buttocks. Microscopically, there are dermal and septal edema, adipocyte degeneration, and numerous mast cells, features…
Taylor NE et al. · Journal of cutaneous pathology · 1 fev 2004
"Lipedema," a special form of obesity syndrome, represents swelling of the legs due to an increase of subcutaneous adipose tissue. In 12 patients with lipedema of the legs and in 12 healthy subjects (controls), fluorescence…
Amann-Vesti BR, Franzeck UK, Bollinger A · Lymphology · 1 dez 2001
Lipedematous alopecia is a rare condition of unknown etiology characterized by a thick, boggy scalp with varying degrees of hair loss that occurs in adult black females, with no clearly associated medical or physiologic…
Fair KP et al. · Journal of cutaneous pathology · 1 jan 2000
The "Lipedema" or "Fatedema" is conditioned by a slight mechanical obstruction of the small lymphatic vessels by the increasing pressure of the growing fat tissue. This lymphostasis in a normal lymphatic vessel system arises only…
Herpertz U · Zeitschrift fur Lymphologie. Journal of lymphology · 1 ago 1995
Lipedema is a chronic vascular disease almost exclusively of female sex, characterized by the deposit of fat on the legs, with an "Egyptian column" shape, orthostatic edema, hypothermia of the skin, alteration of the plantar…
Bilancini S et al. · Angiology · 1 abr 1995
Patients with lipoedema of the typus rusticanus Moncorps show a skin elasticity deficit of the skin of the calf. This is partly due to the derma oedema in the skin of these patients and seems partly to be due to an intrinsic…
Jagtman BA, Kuiper JP, Brakkee AJ · Phlebologie · 1 jan 1984
Sem abstract disponível no PubMed.
Schmitz R · Zeitschrift fur Lymphologie. Journal of lymphology · 1 jul 1981
Sem abstract disponível no PubMed.
Schmitz R · Die Medizinische Welt · 23 mai 1980