ObjectivesLipedema is a chronic condition that predominantly affects women, leading to painful, disproportionate fat distribution in the limbs. This systematic review and meta-analysis aimed to characterize health-related quality…
ObjectiveThis study aimed to comparatively evaluate sleep quality in individuals with lipedema and healthy controls. In addition, the relationships between sleep quality and depression, anxiety, fatigue, and clinical parameters…
Kesiktaş N, Ersoy S, Şirin Ahısha B · Phlebology · 15 out 2026
Background/Objectives: Lipedema is an adipose tissue disorder associated with body-related burden. This study compared orthorexic eating tendencies between women with and without lipedema and examined associations with body-shape…
Doran M, Zincirci DE, Şahan EG · Journal of clinical medicine · 4 out 2026
To compare the efficacies of extracorporeal shock wave therapy (ESWT) and complex decongestive therapy (CDT) in patients with lipedema. This randomized-controlled-study included 33 patients with lipedema, with 11 patients in each…
Türköz MD, Kasap Z, Keleş B · American journal of physical medicine & rehabilitation · 24 set 2026
Individuals with lipoedema may experience negative impacts that are not often identified through current quality-of-life measures. The aim of this study was to explore the experiences of individuals living with pre-existing…
Stellmaker R et al. · International journal of qualitative studies on health and well-being · 18 set 2026
Women with lipedema have an abnormal accumulation of adipose tissue that leads to pain and reduced quality of life (QoL). The impact of lipedema on body image and QoL remains largely unknown. The aim of this study is to explore…
Goodrose-Flores C, Björkhem-Bergman L · PloS one · 14 ago 2026
Recent research suggests that body contouring surgeries may reduce benzodiazepine (BNZ) use in patients with anxiety or depressive disorders. This study explores whether similar benefits occur in women with lipedema-a chronic…
Bruno A, D'Antimi A · Aesthetic plastic surgery · 8 jul 2026
Lipedema is a prevalent chronic condition in women, characterized by a painful and symmetrical accumulation of adipose tissue primarily in the lower limbs. Its diagnosis is based on specific clinical characteristics; however,…
Gursen C et al. · BMC women's health · 20 jun 2026
To compare central sensitization (CS), pressure pain threshold (PPT), and psychosocial factors between women with lipedema and healthy controls and to identify variables associated with CS in lipedema. In this cross-sectional…
Şirin Ahısha B et al. · Aesthetic plastic surgery · 17 jun 2026
Lipedema is a chronic connective tissue disorder characterized by painful subcutaneous adipose accumulation, mainly in the lower extremities. Pain is a hallmark feature, yet its mechanisms remain poorly defined. Neuropathic…
Pervane S, Uzun Ö · Lymphatic research and biology · 8 jun 2026
Lipedema is a chronic adipose tissue disorder primarily affecting women, characterized by abnormal fat accumulation, pain, and reduced mobility. Its impact on sexual function remains underexplored. This study aimed to evaluate…
Recent studies have consistently shown that patients with lipedema are at a higher risk for depression and anxiety. The aim of this study is to identify the psychological factors associated with lipedema syndrome (LS) and their…
Seynhaeve B et al. · Lymphatic research and biology · 6 jun 2026
Lipedema is a chronic adipose tissue disorder predominantly affecting women and is frequently misclassified as obesity. While its physical manifestations are increasingly recognized, less attention has been paid to eating…
Kunzová M · Frontiers in global women's health · 13 fev 2026
BackgroundEndothermal ablation (ETA) is a well-established treatment for chronic venous insufficiency (CVI). However, its effectiveness in patients with concomitant lipedema remains poorly described. Given the distinct…
Reyes Valdivia A et al. · Phlebology · 19 jan 2026
ObjectivesLipedema is a chronic condition that predominantly affects women, leading to painful, disproportionate fat distribution in the limbs. This systematic review and meta-analysis aimed to characterize health-related quality…
This study aimed to evaluate the clinical efficacy of transfer energy capacitive and resistive (TECAR) therapy in females with Stage 2 lipedema, focusing on limb circumference, pain, functional status, and quality of life. A…
Uzun Ö et al. · Turkish journal of physical medicine and rehabilitation · 10 nov 2025
Chronic edema in the lower extremities leads to significant negative effects on the quality of life, body image perception, satisfaction, self-confidence, and self-esteem of affected individuals. The aim of this study was to…
Ersoy S et al. · Revista da Associacao Medica Brasileira (1992) · 27 out 2025
We aimed to assess the sleep quality and the relationship between sleep and fatigue and quality of life in female lipedema patients. A total of 52 patients with lipedema (Group 1) and 40 healthy control subjects (Group 2) were…
Cagliyan Turk A et al. · Lymphatic research and biology · 7 out 2025
To determine the frequency of neuropathic pain in patients with lipedema and to assess the impact of neuropathic pain on quality of life and its correlation with clinical variables. The prospective, descriptive study included 150…
Erden E et al. · Irish journal of medical science · 11 ago 2025
Lipedema is a chronic condition characterized by excessive fat deposition in the hips, buttocks, and lower legs, significantly impacting quality of life. In Czechia, limited research exists on the relationship between lipedema…
Kunzová M, Lagová E, Keith L · Frontiers in global women's health · 24 jul 2025
Lipedema is an adipose tissue disorder involving mostly women. One of the most characteristic lipedema symptoms is painful accumulation of adipose tissue in lower and upper extremities leading to disproportion. Due to the…
Czerwińska M et al. · BMC women's health · 3 jul 2025
Lipedema is a chronic disease in adipose tissue affecting women. The distinctive body appearance in lipedema, often mistaken for obesity, may be detrimental to social life. In our online cross-sectional survey study, conducted…
Falck J et al. · Health care for women international · 8 mai 2025
Lipedema is a chronical progressive disease mostly found in women, characterized by an unproportional increase of fat in the limbs and pain. So far mental perspectives are not acceptably resolved. This study examines patients'…
Kreidel Y et al. · Psychotherapie, Psychosomatik, medizinische Psychologie · 3 abr 2025
The psychosocial and mental health challenges of living with lipoedema are well documented and may influence motivation and confidence with self-care. This article provides a background to the condition, reviewing evidence…
Williams A, McKain L · British journal of community nursing · 1 abr 2025
To explore the experiences of sexual health and intimate relationships in women with lipedema. A qualitative interview study. Sixteen women with lipedema recruited from a national lipedema association group in Sweden…
Falck J et al. · Journal of advanced nursing · 26 mar 2025
Introduction: Lymphedema and lipedema are chronic conditions significantly impacting psychosocial status and quality of life (QOL). However, comparative studies on depression, life satisfaction, functional status, and QoL in…
Yaman A et al. · Lymphatic research and biology · 13 mar 2025
The aim of this study was to explore the functioning of people with lipoedema from their perspective. This was a qualitative study following a phenomenological perspective using individual in-depth interviews with a convenience…
Kloosterman LM et al. · International journal of qualitative studies on health and well-being · 20 fev 2025
This study explored experienced weight stigma, internalised weight bias and depressive symptom severity in lipoedema, a chronic health condition that primarily affects women and involves painful and disproportionate adipose…
Clarke C, Kirby JN, Best T · Clinical obesity · 14 dez 2024
Lipedema is characterized by the painful abnormal deposition of adipose tissue in the lower limbs and is often misdiagnosed as obesity. Considering the numerous bothersome physical symptoms of lipedema, women with lipedema may…
Chachaj A et al. · Advances in clinical and experimental medicine : official organ Wroclaw Medical University · 1 dez 2024
The Health and Safety Execultive lymphoedema model of care was published in 2018 highlighting the lack of dedicated lymphoedema services in Ireland. This led to the introduction of a proof-of-concept primary care specialist…
Morris K et al. · British journal of community nursing · 1 abr 2024
We conducted a comparative study involving 39 female patients with lipedema and group-matched controls at a ratio of 1:5. The primary survey tool was the German Health Update (GEDA 2019/2020-EHIS) questionnaire, which was…
Kempa S et al. · Life (Basel, Switzerland) · 22 fev 2024
The study examines, for the first time, the impact on quality of life after liposuction for lipoedema. The influence of aesthetic plastic interventions and their effects on treatment outcomes has been a major focus of our…
Klöppel M et al. · Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 10 fev 2024
To describe and analyse experiences of living with lipedema. Methods: Individual, semi-structured interviews with a purposive sample of 12 women diagnosed with lipedema and analysed by qualitative content analysis utilizing an…
Dahlberg J et al. · International journal of qualitative studies on health and well-being · 30 dez 2023
Background/Aim: The aim of this study was to determine the frequency of fibromyalgia syndrome (FMS) in patients with lipedema and to evaluate the effects of FMS on anxiety, depression, and quality of life (QoL) in this patient…
Cagliyan Turk A et al. · Lymphatic research and biology · 22 dez 2023
To evaluate the effects of the venous insufficiency (VI) or lipedema on the symptoms, functions, and quality of life (QoL) of patients with knee osteoarthritis (OA). 96 patients with stage 3/4 knee OA were included in the study.…
Lipedema is a widespread disease with painful accumulations of subcutaneous fat in the legs and arms. Often, obesity co-occurs. Many patients suffer from impairment in mobility and mental health. Obesity and mental health in turn…
Aitzetmüller-Klietz M et al. · Journal of clinical medicine · 16 ago 2023
Lipedema is a chronic adipose tissue disorder affecting approximately 11% of women worldwide. The illness is often misdiagnosed as obesity, and because of this, women often struggle in meetings with healthcare providers. Few…
Christoffersen V, Tennfjord MK · International journal of environmental research and public health · 20 jan 2023
The aim of this pilot study was to investigate the effects of defocused and radial shock wave therapy, mesotherapy, and kinesio taping on pain, circumferences of lower limbs, echographic/ elastosonographic pattern of subcutaneous…
Lipoedema is a chronic disease in adipose tissue that almost exclusively affects women during periods of hormonal alterations. Its main symptoms include an abnormal accumulation of subcutaneous fat in the buttock, hips, and legs,…
Lipedema is a chronic and progressive adipose tissue disorder that causes significant morbidity and negatively influences mental health and quality of life, and increases the risk of depression, anxiety, and eating disorders. One…
Al-Wardat M et al. · International journal of environmental research and public health · 21 out 2022
Lipoedema is a progressive adipose (fat) disorder, and little is known about its psychological effect. This study aimed to determine the experiences of physical and mental health and health care across stages of lipoedema.…
Clarke C et al. · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 16 ago 2022
(1) Background: Lipoedema is a disease characterized by excessive bilateral and symmetrical accumulation of subcutaneous tissue in the lower extremities. It is a poorly understood condition, and low awareness of its existence…
Czerwińska M, Ostrowska P, Hansdorfer-Korzon R · International journal of environmental research and public health · 28 set 2021
The association between serum Vitamin D (Vit. D) and mood disorders in lipedema patients has not been investigated. Therefore, the main aim of this study is to investigate the correlation between serum Vit. D, depression and…
Al-Wardat M et al. · Hormone molecular biology and clinical investigation · 29 jul 2021
BACKGROUND Lipedema is a loose connective tissue disease that causes disproportionate subcutaneous fat accumulation on the extremities. As a result of the increased subcutaneous tissue accumulation, lipedema is often confused…
Wright TF, Herbst KL · The American journal of case reports · 14 jun 2021
Lipedema is a type of subcutaneous adipose tissue disorder that affects mainly women. Its main symptom is bilateral fat accumulation on the extremities with associated pain in the affected areas. Despite growing interest in…
Dudek JE, Białaszek W, Gabriel M · BMC women's health · 15 jan 2021
The aim was to quantify and to compare the associations between longitudinal changes in pain and depression in different chronic pain conditions. Data were retrieved from 6 observational cohort studies. From baseline to the…
Angst F et al. · Journal of affective disorders · 19 mai 2020
The aim of this narrative review of the literature was to evaluate and summarize the current literature regarding the effect of lipedema on health-related quality of life (HRQOL) and psychological status. The authors collected…
Alwardat N et al. · Eating and weight disorders : EWD · 6 mai 2019
Lipoedema is a chronic disorder in which excessive fat distribution occurs predominantly from the waist down, resulting in a disproportion between the lower extremities and upper torso. Lipoedema is often not recognized, while…
Romeijn JRM et al. · Dermatology and therapy · 10 mai 2018
Lipedema is a chronic, progressive adipose tissue disorder that may impact the quality of life of women who suffer from it. The main aim of this study was to asses the role of perceived symptom severity, physical and…
Dudek JE et al. · Psychology, health & medicine · 3 abr 2018
This study aimed to explore patients' perceptions regarding the impact that lower limb chronic oedema has on their quality of life (QoL). A quantitative descriptive design was used to collect data from patients with lower limb…
Greene A, Meskell P · International wound journal · 4 ago 2016
Lipoedema is a chronic, progressive adipose disorder of unknown etiology, often underdiagnosed or misdiagnosed as obesity. It manifests itself with accumulation of the fat in lower parts of the body and associated edema and, due…
Dudek JE, Białaszek W, Ostaszewski P · Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 28 jul 2015