Lipedema is a chronic adipose tissue disorder that predominantly affects women, although some rare cases do occur in men. We report the case of a 32-year-old man with symmetrical, lower-limb fat accumulation, foot sparing, pain,…
Kaefer M et al. · Jornal vascular brasileiro · 9 out 2026
A previously healthy 35-year-old woman developed recurrent syncope and dyspnoea two days after extensive thigh liposuction for lipedema. CT pulmonary angiography revealed a large saddle embolus with peripheral emboli. Fat…
Muhammad MGF et al. · Ugeskrift for laeger · 21 set 2026
Hyperechoic subcutaneous nodules in lipedema may mimic angiolipomas but represent an inflammatory and hypoxic-ischemic process rather than a neoplasia, despite tissue expansion. As the painful nodules expand, biopsy is…
Lower extremity swelling has a broad differential diagnosis, including lymphedema, obesity-induced lymphedema, phlebolymphedema, and lipedema. Although these conditions may appear similar clinically, their pathophysiology and…
Oh S et al. · Journal of clinical imaging science · 19 ago 2026
Cashew nut allergy is increasing globally and may cause cross-allergic reactions to seed kernels from botanically related plants, including citrus. A woman in her twenties with a known nut allergy developed anaphylaxis after…
Kahrs GE, Lied GA · Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 14 jul 2026
Lipedema is a lipodystrophic disease characterized primarily by a disproportionate increase in lower body subcutaneous fat. Although moderate weight loss decreases lower body fat mass in women with obesity and lipedema, it is…
De Girolamo G et al. · JCEM case reports · 27 fev 2026
Lipedema is a multifactorial disorder with a negative evolutionary trend, influenced by genetic, hormonal, metabolic, and vascular factors that are not fully understood. Inflammation is a typical feature of lipedema and can be…
Cannataro R, Abrego-Guandique DM, Cione E · Frontiers in nutrition · 29 jan 2026
Lipedema is a chronic adipose tissue disorder primarily affecting women, marked by abnormal, symmetrical, and disproportionate accumulation of subcutaneous fat in the lower limbs and sometimes in the arms, with hands and feet…
Kuttiatt VS et al. · Journal of postgraduate medicine · 10 dez 2025
Lipedema is a clinical entity that deserves special attention, as it predominantly affects women during specific hormonal phases such as menarche, pregnancy and menopause. Among the available treatments, surgery is considered the…
Parizotto NA et al. · Lasers in medical science · 15 out 2025
Lipedema is a chronic adipose tissue disorder traditionally considered to affect almost exclusively women, with recent estimates suggesting approximately 0.2% prevalence in men worldwide; the condition remains underdiagnosed in…
The Ketogenic Diet (KD) is currently the most widely studied nutritional approach for patients with lipedema, although its use may cause important drawbacks especially in case of comorbidities. A Modified Mediterranean Diet…
Fedre B, Dessalvi S, Boccardo F · Lymphology · 1 jan 2025
Routine cold-water immersion (CWI) is typically suggested to reduce inflammation, a hallmark property of lipedema. Lipedema is a connective tissue disorder with a genetic component that presents with a disproportionate…
Schwartz JS et al. · Plastic and reconstructive surgery. Global open · 5 dez 2024
This case report explores the use of radio electric asymmetric conveyor (REAC) technology for chronic pain management, functional limitations, and metabolic dysfunction in a 67-year-old female with rheumatoid arthritis, advanced…
Renck AC, Fontani V, Rinaldi S · Cureus · 23 nov 2024
Lipedema is a debilitating chronic condition predominantly affecting women, characterized by the abnormal accumulation of fat in a symmetrical, bilateral pattern in the extremities, often coinciding with hormonal imbalances.…
Kaftalli J et al. · European review for medical and pharmacological sciences · 1 dez 2023
Lipedema is a pathologic accumulation of adipose tissue in the subcutaneous layer of the extremities. This connective tissue disorder, which predominately affects females, is often misdiagnosed despite an incidence of ∼11%.…
Bouillon VN et al. · Aesthetic surgery journal. Open forum · 22 set 2023
Lipedema is a chronic and progressive disease that may compromise lymphatic function. Although suction-assisted lipectomy (SAL) is considered a safe treatment for lipedema patients, the lymphatic repercussions of this surgical…
Vitorasso CdSR et al. · Plastic and reconstructive surgery. Global open · 21 jun 2023
The lipedematous scalp (LS) is characterized by a thickened scalp because of the increased thickness of the subcutaneous fat layer. When the soft and boggy scalp is associated with shortened hairs and hair loss, it is referred to…
Hu D, Yang S · The American Journal of dermatopathology · 1 set 2022
BACKGROUND Lipedema is a loose connective tissue disease characterized by disproportionate subcutaneous adipose tissue hypertrophy in the extremities. There is evidence of impaired lymphatic function in women with lipedema at all…
Wright TF, Herbst KL · The American journal of case reports · 11 jul 2022
The aim of the present case study was to report the 3-year follow-up of a male patient with lipedema and subclinical systemic lymphedema evaluated using multi-segment bioimpedance. The report describes the case of a 53-year-old…
Pereira de Godoy LM, Guerreiro Godoy MdF, Pereira de Godoy JM · Journal of medical cases · 2 jun 2022
Lipedema is a pathology of adipose tissue, still of unclear etiology and challenging to diagnose. For these reasons, a therapeutic approach is also complex and sometimes controversial. The inflammation state present in lipedema…
Cannataro R et al. · Life (Basel, Switzerland) · 15 dez 2021
BACKGROUND Lipedema is a chronic progressive disease characterized by the abnormal accumulation of fat in the subcutaneous region. Both medical and surgical treatments have been described in international guidelines; however, the…
Amato ACM, Benitti DA · The American journal of case reports · 6 dez 2021
The novel use of cryolipolysis via icepacks, a readily available and inexpensive device, is described for lipoedematous scalp with subjective and objective relief. This is a simple solution to a troublesome, intractable condition…
Kharkar V, Vishwanath T, Kamble P · Clinical and experimental dermatology · 12 out 2021
Objective: Lipedema is a relatively common yet debilitating and often misdiagnosed lipodystrophy that mainly affects females. Very little is known about the etiology and pathophysiology of the disease. However, due to its high…
Bertlich M et al. · GMS Interdisciplinary plastic and reconstructive surgery DGPW · 22 set 2021
BACKGROUND Lipedema is a loose connective tissue disease that causes disproportionate subcutaneous fat accumulation on the extremities. As a result of the increased subcutaneous tissue accumulation, lipedema is often confused…
Wright TF, Herbst KL · The American journal of case reports · 14 jun 2021
BACKGROUND Lipedema is a common condition that presents as excessive fat deposition in the extremities, initially sparing the trunk, ankles, and feet, and is found mainly in women, usually occurring after puberty or pregnancy.…
Wright TF, Herbst KL · The American journal of case reports · 7 mai 2021
A 53-year-old man was admitted to our hospital with a history of a right lung nodule which had gradually increased in size. Wedge resection of the right middle lobe using video-assisted thoracoscopic surgery (VATS) was performed…
Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric age. It is characterized by boggy thickening of the scalp predominantly located at the vertex and occiput, which acquires a…
Míguez-Martín L et al. · Dermatology online journal · 15 mai 2020
Compression therapy is the mainstay of treatment in venous and lymphatic diseases. Optimisation of compression therapy is not a new concept, but, in the UK, the use of 24-hour compression therapy as part of the maintenance phase…
Phillips N, Lawrance S · British journal of community nursing · 1 abr 2020
Lipoedema is a progressive disorder that is characterized by an abnormal distribution of subcutaneous adipose tissue, which results in a disproportion between the extremities and the trunk. This vascular/dermatological disease…
A 66-year-old African woman suffered from a boggy thickening of the scalp in the frontoparietal area and the vertex accompanied by headache since infancy. In her thirties, she developed diffuse hair loss in the same area.…
Accaputo O et al. · Case reports in dermatology · 23 jan 2019
Limb lymphedemas are due to a malfunction of the lymphatic system responsible for lymph stasis in the interstitial tissue and secondarily to an increase in the volume of the affected limb. They are divided into primary lymphedema…
Agharbi F · The Pan African medical journal · 28 dez 2018
Unilateral lower extremity edema below the knee commonly results from deep venous thrombosis, venous insufficiency, or lymphedema. The patient history, a physical examination, and lower extremity venous duplex ultrasound often…
Mutluer FO et al. · Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir · 1 dez 2018
Methemoglobinemia is characterized by an increased level of methemoglobin (MetHb) in the peripheral blood. MetHb levels increase after tumescent anesthesia and need to be monitored. If a patient becomes symptomatic and/or the…
Wollina U, Koch A, Heinig B · Wiener medizinische Wochenschrift (1946) · 22 out 2018
Lipedematous scalp, with or without alopecia, is a poorly known and rarely reported entity. It was first described in 1935 by Cornbleet. It involves increased thickness of the subcutaneous tissue of the scalp, responsible for an…
Chaplain L et al. · Annales de dermatologie et de venereologie · 16 out 2017
Self-management and the use of adjustable velcro compression wraps are not new concepts and quite often both can form part of the maintenance phase of treatment in those with lymphoedema or lipoedema, as well as those diseases in…
Lee N, Pugh S, Cooper R · British journal of community nursing · 1 out 2017
Liposuction is a procedure commonly performed in the UK usually with a low incidence of serious sequelae; however with larger patients and increased volumes of lipoaspirate, complications have been reported more frequently. One…
Ali A, Theobald G, Arshad MA · BMJ case reports · 25 set 2017
Neutrophilic dermatosis (ND) confined to postmastectomy lymphedema, localized Sweet syndrome, is a newly recognized disease. In this study, the authors describe a 44-year-old obese woman with chronic myelogenous leukemia in…
Ainechi S, Carlson JA · The American Journal of dermatopathology · 1 fev 2016
Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and…
Pavlov-Dolijanovic SR et al. · Rheumatology international · 1 mai 2014
In a 66-year-old obese woman (WHO stage III, BMI 51 kg/m2) pronounced osteoarthritis of the right knee was diagnosed. Because of progressive chronic pain of the right knee joint her walking distance was limited to a few meters.…
Brinkmann V et al. · Deutsche medizinische Wochenschrift (1946) · 1 abr 2014
Bone morphogenetic proteins (BMPs) induce osteogenesis, making them useful for decreasing time to union and increasing union rates. Although the advantages of BMP-2 as a substitute for iliac crest graft have been elucidated, less…
Merrick MT, Hamilton KD, Russo SS · The spine journal : official journal of the North American Spine Society · 22 jun 2013
A grossly obese woman was wrongly diagnosed throughout her adult life of having lymphoedema. Her condition was subsequently confirmed as lipoedema, an entirely different condition, which is noted in medical text books but is…
Goodliffe JM et al. · BMJ case reports · 24 mai 2013
A 54-year-old female patient reported that a characteristic of her family was 'fat legs' with postural edema since adolescence. Over the years the patient had been gaining weight with an increase in fatty tissue in the legs and…
Godoy MdFG et al. · Case reports in dermatology · 23 out 2012
The pathophysiology of skin diseases associated with monoclonal gammopathies is generally unknown. Our aim was to investigate whether a monoclonal gammopathy could be a causal factor in progressive lymphedema. We describe a 75…
Lipedema is a condition characterized by abnormal deposition of adipose tissue in the lower extremities leading to circumferential bilateral lower extremity enlargement typically seen extending from the hips to the ankles.…
Peled AW, Slavin SA, Brorson H · Annals of plastic surgery · 1 mar 2012
Lipedema is an underdiagnosed syndrome of unclear etiology, characterized by symmetric painful enlargement of the buttocks and lower extremities, which spares the feet. This enlargement is caused by the deposition of adipose…
Pascucci A, Lynch PJ · Dermatology online journal · 15 set 2010
The aim of the current study was to alert about dermatological alterations in the clinical evolution of lipo-lymphedema. The case of a 48-year-old patient is reported with clinical diagnosis of stage II lipo-lymphedema treated in…
Pereira De Godoy JM et al. · Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia · 1 ago 2010
Lipedema is a disease with unknown etiology presenting as bilateral and symmetric enlargement of the lower extremities due to subcutaneous deposition of the adipose tissue. Here we describe the histopathological features of the…
Suga H et al. · Journal of cutaneous pathology · 1 dez 2009
We report a familial Sotos syndrome in two children, boy and girl, aged 17 and 8 years, and in their 44 year old mother, who displayed normal intelligence at adult age, but suffered from insulin dependent diabetes mellitus,…
Zechner U et al. · European journal of medical genetics · 21 jun 2009
Lipofibromatosis is a slow-growing, childhood soft-tissue neoplasm that is often confused with other conditions. We report a patient with lipofibromatosis causing extremity enlargement at birth. The lesion initially was thought…
Greene AK et al. · Annals of plastic surgery · 1 jun 2009
Lipedema is characterized by symmetric lower extremity enlargement secondary to the deposition of fat. Lipedema is not rare, but it is commonly misdiagnosed as lymphedema. We describe a 20-year-old woman with massive lower…
Fonder MA, Loveless JW, Lazarus GS · Journal of the American Academy of Dermatology · 1 ago 2007
Lipoedema is a form of lipodistrophy, which consists of abnormal accumulation of fat in subcutaneous tissue of the lower limbs. It does not cause any disease and it has not been reported association with malignity. We describe a…
Ekmekci TR et al. · Journal of the European Academy of Dermatology and Venereology : JEADV · 1 mai 2005
Lipedema refers to the abnormal deposition of subcutaneous fat causing a striking enlargement of the lower extremities that is out of proportion to the upper body. Most clinicians are unaware of this disease and thus it is seldom…
Koss T et al. · Journal of the American Academy of Dermatology · 1 jun 2004
Painful fat syndrome or lipoedema is a distinct clinical condition, characterised by bilateral and symmetrical enlargement of the upper and lower leg with tenderness, but excluding the feet. Lipoedema occurs almost exclusively in…
Chen S et al. · British journal of plastic surgery · 1 abr 2004
Lipedema is a condition characterized by diffuse, bilaterally symmetrical, painful swelling of the legs and buttocks. Microscopically, there are dermal and septal edema, adipocyte degeneration, and numerous mast cells, features…
Taylor NE et al. · Journal of cutaneous pathology · 1 fev 2004
We describe a 52 year-old woman in whom lymphedema primarily of the abdominal wall was superimposed on lipedema resulting in an abdomen of enormous dimensions with marked impairment of ambulation. Treatment consisted of…
Lipedema never reveals clinical picture of extreme lymphedema-elephantiasis, and skin signs and complications have not been observed. Aim of this paper is to present a case of lipedema with the initial lymphedema in which, after…
Ignjatović M, Jevtić M, Cerović S · Vojnosanitetski pregled · 1 jan 2000
Lipedema represents a form of lipodistrophy, which consists of abnormal accumulation of fat in subcutaneous tissue of the lower limbs with consecutive development of lymphostasis and lymphedema. The aim of this article was to…
Ignjatović M, Cerović S · Vojnosanitetski pregled · 1 jan 1999
Two cases of lipedema are presented. They illustrate this clinical syndrome which occurs almost exclusively in women and presents as grossly enlarged legs, thighs and buttocks. The etiology remains uncertain. Although…
Lipedema of the legs is a symmetrical thickening of upper and lower leg and topically accentuated fat pads. The back of the foot is usually free of swelling. Pathogenetically it is a disturbance of the distribution pattern of…
Brunner U · Schweizerische medizinische Wochenschrift · 14 ago 1982