https://lipedema360.com.br A ciência do lipedema, atualizada todo dia. pt-BR https://lipedema360.com.br/artigos/42961804 https://lipedema360.com.br/artigos/42961804 Fri, 30 Oct 2026 12:00:00 GMT Estudo original ObjectivesLipedema is a progressive adipose disorder affecting women, with diagnosis often delayed due to symptom overlap and lack of validated tools. This study assesses the Turkish version of the Lipedema Screening Questionnaire (T-LSQ) through cultural adaptation and psychometric evaluation. The aim of this study was to investigate selected psychometric properties of the Turkish version of the Lipedema Screening Questionnaire (T-LSQ).MethodsThe study involved 59 female volunteers diagnosed… https://lipedema360.com.br/artigos/42960549 https://lipedema360.com.br/artigos/42960549 Fri, 30 Oct 2026 12:00:00 GMT Estudo original BackgroundLipedema is a chronic pain disorder characterized by disproportionate adipose tissue accumulation and pain of the affected extremities. While medical compression therapy is recommended for pain reduction, evidence regarding the additional benefit of intermittent pneumatic compression (IPC) remains limited. The aim of this study was to evaluate the effect of IPC on pain in patients with lipedema already receiving compression therapy.MethodsRetrospective investigator-initiated analysis… https://lipedema360.com.br/artigos/42956381 https://lipedema360.com.br/artigos/42956381 Thu, 29 Oct 2026 12:00:00 GMT Estudo original BackgroundLipedema is a chronic adipofascial disorder characterized by pain, edema and progressive functional impairment. Conservative treatment is widely recommended as first-line therapy, but evidence on its impact on disease-specific quality of life remains limited. This study evaluated changes in quality of life following 6 months of partially standardized conservative treatment in women with lipedema, using the Lipedema Symptom Assessment Questionnaire (QuASiL).MethodsThis prospective… https://lipedema360.com.br/artigos/42955484 https://lipedema360.com.br/artigos/42955484 Thu, 29 Oct 2026 12:00:00 GMT Estudo original Lipoedema and familial partial lipodystrophy (FPLD) are rare adipose tissue disorders frequently misclassified as common obesity. Clinical assessment and body mass index (BMI) alone may fail to capture regional fat distribution, delaying recognition and suboptimal management of metabolic complications. To evaluate whether dual-energy X-ray absorptiometry (DXA)-derived regional fat distribution indices may provide complementary phenotyping information for distinguishing clinically characterized… https://lipedema360.com.br/artigos/42933366 https://lipedema360.com.br/artigos/42933366 Mon, 26 Oct 2026 12:00:00 GMT Estudo original BackgroundLipedema is a chronic condition that is increasingly being detected and gaining public awareness; however, strongly validated therapeutic options are lacking.ObjectivesGiven need for appropriate lipedema management approaches and demand for new studies and methods, this investigation aimed to compare effects of a combined treatment consisting of extracorporeal shock wave therapy (ESWT), manual lymphatic drainage (MLD), intermittent pneumatic compression (IPC), and lifestyle… https://lipedema360.com.br/artigos/42932247 https://lipedema360.com.br/artigos/42932247 Mon, 26 Oct 2026 12:00:00 GMT Estudo original Pain and reduced mobility are common among people living with lipoedema. While well-fitting compression garments can help alleviate these symptoms, poorly fitting garments may be ineffective and contribute to significant material waste. This survey explored compression prescription experiences of healthcare practitioners and compared them with those of people living with lipoedema. Online surveys were completed by 373 people living with lipoedema in 2024 and 24 healthcare practitioners in 2025.… https://lipedema360.com.br/artigos/42921698 https://lipedema360.com.br/artigos/42921698 Sat, 24 Oct 2026 12:00:00 GMT Revisão IntroductionLipedema is a chronic adipose and connective tissue disorder in which pain is classically localized to affected limb tissue. However, some patients report joint, periarticular, myotendinous, or axial pain, with fatigue, sleep disturbance, and exercise intolerance. When symptoms become widespread, the presentation may resemble fibromyalgia (FM), creating a diagnostic challenge for phlebologists.ObjectivesTo provide a clinical framework for distinguishing characteristic lipedema… https://lipedema360.com.br/artigos/42925123 https://lipedema360.com.br/artigos/42925123 Fri, 23 Oct 2026 12:00:00 GMT Estudo original BackgroundChronic venous disorders and lipedema are complex and frequently underdiagnosed conditions characterized by heterogeneous clinical presentations, progressive tissue remodeling, and substantial variability in treatment response assessment. Despite advances in minimally invasive vascular interventions, longitudinal evaluation in routine clinical practice continues to rely heavily on subjective interpretation, non-standardized comparative imaging, and physician-dependent assessment… https://lipedema360.com.br/artigos/42908315 https://lipedema360.com.br/artigos/42908315 Thu, 22 Oct 2026 12:00:00 GMT Estudo original To evaluate which factors are associated with change in lymphedema-specific quality of life (QoL) and relative volume difference in the maintenance phase after a multidisciplinary intensive treatment program in patients with lower limb lymphedema(LLL). In this retrospective study, patients received a multidisciplinary intensive treatment followed by a maintenance phase. In this maintenance phase, patients were advised to perform skin care and exercises and to wear compression garments.… https://lipedema360.com.br/artigos/42897246 https://lipedema360.com.br/artigos/42897246 Mon, 19 Oct 2026 12:00:00 GMT Carta / editorial This Letter to the Editor documents several verifiable internal inconsistencies in the article by Bruno and D'Antimi, including contradictory statements on study design, a level-of-evidence rating incompatible with the stated methods, contradictory informed-consent statements, and references to a procedure and outcome domain that do not correspond to the study performed. A correction or clarification is requested.Level of Evidence V This journal requires that authors assign a level of evidence… https://lipedema360.com.br/artigos/42893453 https://lipedema360.com.br/artigos/42893453 Sun, 18 Oct 2026 12:00:00 GMT Revisão BackgroundLipedema is a chronic condition that predominantly affects women and is commonly associated with pain, edema, and functional impairment. Conservative physiotherapy interventions are frequently recommended; however, the scope and characteristics of the available evidence remain unclear.ObjectiveTo map the existing evidence on conservative physiotherapy interventions for lipedema, focusing on intervention types, outcomes assessed, and methodological characteristics.MethodsA scoping… https://lipedema360.com.br/artigos/42912067 https://lipedema360.com.br/artigos/42912067 Fri, 16 Oct 2026 12:00:00 GMT Estudo original The aim of this study was to characterize global scientific output on lipedema from 2000 to 2025 and identify emerging thematic trends, with emphasis on the emergence of immunological research. Publications indexed in Google Scholar, PubMed, Crossref, OpenAlex, and Scopus were retrieved using the terms "lipedema" OR "lipoedema." Records were deduplicated by normalized title matching and DOI cross-referencing. Bibliometric indicators computed included publication volume, citation metrics, field… https://lipedema360.com.br/artigos/42886501 https://lipedema360.com.br/artigos/42886501 Fri, 16 Oct 2026 12:00:00 GMT Estudo original ObjectivesLipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, lower extremity pain, functional impairment, and reduced quality of life. Although pain is a cardinal symptom, its underlying mechanisms remain incompletely understood. This study aimed to characterize sensitization-related pain phenotypes in women with lipedema by examining central sensitization (CS) and neuropathic -like pain features and their associations with lower extremity… https://lipedema360.com.br/artigos/42886234 https://lipedema360.com.br/artigos/42886234 Fri, 16 Oct 2026 12:00:00 GMT Estudo original ObjectivesTo investigate the clinical and ultrasonographic changes associated with radial extracorporeal shock wave therapy (rESWT) in women with lipedema.MethodsThis prospective, single-arm study included 40 women with lipedema who completed six sessions of rESWT administered twice weekly to the index lower limb. Treatment consisted of 3000-6000 impulses at 15 Hz and 3-4 bar. Participants were evaluated at baseline (T0), immediately after treatment (T1), and at 4-week follow-up (T2). Outcomes… https://lipedema360.com.br/artigos/42880401 https://lipedema360.com.br/artigos/42880401 Thu, 15 Oct 2026 12:00:00 GMT Estudo original ObjectivesTo determine the prevalence of chronic venous insufficiency (CVI) in patients with lipedema, characterize venous reflux patterns and CEAP clinical classes, and evaluate associations with demographic and lipedema-related characteristics.MethodsThis retrospective, single-center observational study included adults with lipedema evaluated between January 2023 and December 2025. Of 120 patients screened, 50 were excluded because of incomplete venous Doppler ultrasonography, clinical, or… https://lipedema360.com.br/artigos/42880360 https://lipedema360.com.br/artigos/42880360 Thu, 15 Oct 2026 12:00:00 GMT Estudo original ObjectiveThis study aimed to comparatively evaluate sleep quality in individuals with lipedema and healthy controls. In addition, the relationships between sleep quality and depression, anxiety, fatigue, and clinical parameters were investigated.MethodsThis cross-sectional study included 30 women with lipedema and 30 healthy female controls aged 18-75 years. Pain severity in individuals with lipedema was assessed using the Visual Analog Scale (VAS). Lipedema stage, comorbidities, and symptom… https://lipedema360.com.br/artigos/42864541 https://lipedema360.com.br/artigos/42864541 Mon, 12 Oct 2026 12:00:00 GMT Estudo original Lipedema is a chronic disorder of adipose tissue marked by disproportionate fat accumulation in the extremities and persistent pain, which significantly impairs quality of life. Although liposuction has been adopted as a therapeutic intervention beyond aesthetic purposes, the extent and long-term persistence of pain reduction after surgery have not been fully quantified. This systematic review and meta-analysis followed PRISMA guidelines. Multiple electronic databases were searched from… https://lipedema360.com.br/artigos/42921064 https://lipedema360.com.br/artigos/42921064 Fri, 09 Oct 2026 12:00:00 GMT Estudo original There are no validated Norwegian disease-specific patient-reported outcome measures (PROMs) assessing quality of life (QoL) in females with lipedema, limiting evaluation of treatment effect in clinical practice and research. To translate and validate a Norwegian translation of the LIPQOL questionnaire. A cross-sectional validation study was performed in 432 females with lipedema in Norway. Descriptive statistics and floor and ceiling effects were assessed. The psychometric properties of the… https://lipedema360.com.br/artigos/42890151 https://lipedema360.com.br/artigos/42890151 Fri, 09 Oct 2026 12:00:00 GMT Relato de caso Lipedema is a chronic adipose tissue disorder that predominantly affects women, although some rare cases do occur in men. We report the case of a 32-year-old man with symmetrical, lower-limb fat accumulation, foot sparing, pain, easy bruising, and a positive family history of lipedema. His first-degree female cousin exhibited the classic phenotype. Dual-energy X-ray absorptiometry demonstrated greater fat accumulation in the gynoid than in the android and visceral regions, reinforcing a… https://lipedema360.com.br/artigos/42847205 https://lipedema360.com.br/artigos/42847205 Thu, 08 Oct 2026 12:00:00 GMT Estudo original ObjectivesThis study aimed to determine the frequency of probable lipedema among women with lower extremity pain (LEP) using a validated screening questionnaire and to examine its associations with neuropathic pain (NP) characteristics, functional status, psychological symptoms, and health-related quality of life (HRQoL).MethodsThis prospective questionnaire-based case-control study included 133 women, comprising 68 women with LEP and 65 age-matched healthy controls. Participants were evaluated… https://lipedema360.com.br/artigos/42939576 https://lipedema360.com.br/artigos/42939576 Wed, 07 Oct 2026 12:00:00 GMT Revisão Aim: This narrative review summarises evidence on pathogenetic mechanisms of adipose tissue remodelling and adipokine dysregulation in lipedema, focusing on adipocyte hypertrophy and hyperplasia, fibrosis, microcirculatory and lymphatic dysfunction, immune-cell alterations, and diagnostic biomarkers. Methods: We conducted a narrative search in PubMed, Scopus, and Google Scholar from database inception to September 2026, including publications from 2001 to 2026. Search terms included "lipedema",… https://lipedema360.com.br/artigos/42909292 https://lipedema360.com.br/artigos/42909292 Wed, 07 Oct 2026 12:00:00 GMT Estudo original Lipedema is a chronic adipose tissue disorder characterized by a disproportionate accumulation of painful subcutaneous fat on the extremities. Manual lymphatic drainage (MLD) is routinely used as therapeutic intervention, but its immediate physiological effects remain unclear. We evaluated the immediate impact of MLD on tissue composition in Lipedema using multiparametric Magnetic-resonance-imaging (MRI). Fifteen women with Lipedema (5 women each for stages I/II/III; median age 43.7 [20.4-68.8]… https://lipedema360.com.br/artigos/42882518 https://lipedema360.com.br/artigos/42882518 Wed, 07 Oct 2026 12:00:00 GMT Revisão Lipedema is a chronic, predominantly female disorder characterized by disproportionate regional expansion of subcutaneous adipose tissue, pain, tenderness, and easy bruising. Reported abnormalities involve adipocytes, stromal/progenitor cells, microvascular and immune compartments, extracellular matrix (ECM), and, variably, lymphatic function, but their causal and temporal relationships remain unresolved. Here, we propose the adipovascular unit (AVU) as a systems-level framework that links… https://lipedema360.com.br/artigos/42839854 https://lipedema360.com.br/artigos/42839854 Wed, 07 Oct 2026 12:00:00 GMT Carta / editorial https://lipedema360.com.br/artigos/42882140 https://lipedema360.com.br/artigos/42882140 Sun, 04 Oct 2026 12:00:00 GMT Estudo original Background/Objectives: Lipedema is an adipose tissue disorder associated with body-related burden. This study compared orthorexic eating tendencies between women with and without lipedema and examined associations with body-shape concern and psychological symptoms. Methods: This controlled cross-sectional study included 44 women with lipedema and 44 women without lipedema. Participants completed the Düsseldorf Orthorexia Scale (DOS), Body Shape Questionnaire (BSQ), and Hospital Anxiety and… https://lipedema360.com.br/artigos/42823795 https://lipedema360.com.br/artigos/42823795 Fri, 02 Oct 2026 12:00:00 GMT Estudo original https://lipedema360.com.br/artigos/42919066 https://lipedema360.com.br/artigos/42919066 Thu, 01 Oct 2026 12:00:00 GMT Revisão https://lipedema360.com.br/artigos/42889398 https://lipedema360.com.br/artigos/42889398 Thu, 01 Oct 2026 12:00:00 GMT Revisão A progressive disease, lipedema is characterized by bilaterally symmetrical and disproportional accumulation of subcutaneous adipose tissue (SAT) in the extremities, leading to severe pain, inflammation, and mobility issues. Lipedema predominantly affects women in all stages of life and treatment options are currently limited as patients' conditions can only be improved to a limited extent by diet or exercise. The pathogenesis of lipedema remains poorly understood and a reliable diagnostic… https://lipedema360.com.br/artigos/42767624 https://lipedema360.com.br/artigos/42767624 Thu, 01 Oct 2026 12:00:00 GMT Revisão Lipoedema is a painful adipose tissue disorder marked by disproportionate limb fat and often misclassified as generalized obesity or lymphoedema. This review examines its metabolic phenotype and implications for cardiometabolic assessment and management. PubMed/MEDLINE was searched from inception through May 2026 for studies on lipoedema, obesity, body composition, metabolic risk, insulin resistance, diabetes, lifestyle interventions, pharmacotherapy and liposuction. Relevant clinical,… https://lipedema360.com.br/artigos/42806128 https://lipedema360.com.br/artigos/42806128 Mon, 28 Sep 2026 12:00:00 GMT Estudo original The aim of this study was to compare serum adiponectin, leptin, resistin, irisin, and galectin-3 levels between patients with lipedema and healthy controls, and to examine their relationship with subcutaneous adipose tissue thickness. In this cross sectional case control study, 40 female patients with lipedema and 36 age and body mass index matched healthy controls were included. Serum levels of adiponectin, leptin, resistin, irisin, and galectin-3 were measured using enzyme-linked… https://lipedema360.com.br/artigos/42927387 https://lipedema360.com.br/artigos/42927387 Thu, 24 Sep 2026 12:00:00 GMT Estudo original The clinical course of lipedema in women receiving hormonal treatment for concomitant estrogen-dependent gynecological disorders remains insufficiently characterized. This study aimed to describe gynecological and lipedema-related manifestations during routine follow-up in women receiving subcutaneous gestrinone implants for gynecological indications. This retrospective, descriptive case series included 50 women with stage II or III lipedema and concomitant estrogen-dependent gynecological… https://lipedema360.com.br/artigos/42785926 https://lipedema360.com.br/artigos/42785926 Thu, 24 Sep 2026 12:00:00 GMT Estudo original To compare the efficacies of extracorporeal shock wave therapy (ESWT) and complex decongestive therapy (CDT) in patients with lipedema. This randomized-controlled-study included 33 patients with lipedema, with 11 patients in each of the three groups. The first group received ESWT alone, the second group received CDT alone, and the third group received ESWT followed by CDT within the session for six treatment sessions. Assessments were performed at baseline and two weeks after treatment… https://lipedema360.com.br/artigos/42921232 https://lipedema360.com.br/artigos/42921232 Wed, 23 Sep 2026 12:00:00 GMT Estudo original This study aimed to compare 12-week changes in body composition and anthropometric parameters between standard-dose and lower-dose tirzepatide escalation regimens in women with lipedema, with particular emphasis on changes in fat mass and skeletal muscle mass. This retrospective observational study included 100 women with lipedema receiving tirzepatide during routine clinical care. Participants were classified into lower-dose (n = 50) and standard-dose (n = 50) groups according to their… https://lipedema360.com.br/artigos/42776843 https://lipedema360.com.br/artigos/42776843 Wed, 23 Sep 2026 12:00:00 GMT Estudo original BackgroundLipedema is a frequently misdiagnosed chronic condition that significantly impacts patients' quality of life. As artificial intelligence (AI)-based large language models (LLMs) become increasingly integrated into healthcare communication, their accuracy and consistency in providing patient-centered information require thorough evaluation, especially in rare diseases like lipedema. Therefore, this study aimed to evaluate the accuracy and reproducibility of responses generated by… https://lipedema360.com.br/artigos/42894944 https://lipedema360.com.br/artigos/42894944 Mon, 21 Sep 2026 12:00:00 GMT Relato de caso A previously healthy 35-year-old woman developed recurrent syncope and dyspnoea two days after extensive thigh liposuction for lipedema. CT pulmonary angiography revealed a large saddle embolus with peripheral emboli. Fat embolism was initially suspected; however, imaging findings and laboratory parameters supported a thromboembolic origin. Treatment with anticoagulation was complicated by postoperative bleeding. This case report highlights the importance of considering both fat embolism and… https://lipedema360.com.br/artigos/42766118 https://lipedema360.com.br/artigos/42766118 Mon, 21 Sep 2026 12:00:00 GMT Estudo original IntroductionAfter unification of diagnostic criteria for lipedema through guidelines and consensus documents as a fat-disproportion between abdomen and extremities with pain in the affected area, reduced by compression, expensive treatment options like liposuction should be reserved to affected women. Whilst the diagnosis of lipedema is obviously clinic, technical investigations or clear cut-offs shall help avoiding misuse of resources. The aim of this study was to find differentiation criteria… https://lipedema360.com.br/artigos/42758894 https://lipedema360.com.br/artigos/42758894 Fri, 18 Sep 2026 12:00:00 GMT Estudo original Individuals with lipoedema may experience negative impacts that are not often identified through current quality-of-life measures. The aim of this study was to explore the experiences of individuals living with pre-existing lipoedema and their perceptions of how these experiences influence quality of life. Participants with a prior diagnosis of lipoedema participated in a single semi-structured interview or focus group. These interviews/focus groups were transcribed verbatim, allowing for an… https://lipedema360.com.br/artigos/42812451 https://lipedema360.com.br/artigos/42812451 Tue, 15 Sep 2026 12:00:00 GMT Estudo original Low-carbohydrate diets (LCDs) have been suggested as a potential treatment option for females with lipedema, due to their superiority in reducing pain, possibly through improvements in insulin dynamics. The objective of this secondary analysis was to compare changes in markers of glucose and insulin dynamics after a low-carbohydrate versus low-fat low-energy diets in females with lipedema and obesity. A secondary objective was to investigate potential associations between changes in glucose and… https://lipedema360.com.br/artigos/42866530 https://lipedema360.com.br/artigos/42866530 Sat, 12 Sep 2026 12:00:00 GMT Estudo original The aesthetic-functional planning of the lower limbs is frequently conducted empirically, using idiosyncratic markings and limited standardization among specialists who work in this field. The absence of a common topographic language restricts clinical communication, technical reproducibility, documentation of results, and the integration between the aesthetic approach and the vascular/lymphatic assessment of the segment. This is a descriptive study of methodological development. Based on a… https://lipedema360.com.br/artigos/42742114 https://lipedema360.com.br/artigos/42742114 Sat, 12 Sep 2026 12:00:00 GMT Estudo original To comprehensively characterize pain in women with lipedema and evaluate its relationship with central sensitization, neuropathic pain characteristics, pain sensitivity, sleep quality, and quality of life. : A cross-sectional controlled study. Department of Physical Medicine and Rehabilitation, Ankara Bilkent City Hospital. 59 women with Type 2-3, Stage 1-3 lipedema and 59 age-matched healthy controls. Pain intensity, neuropathic pain characteristics, symptoms related to central sensitization,… https://lipedema360.com.br/artigos/42722924 https://lipedema360.com.br/artigos/42722924 Thu, 10 Sep 2026 12:00:00 GMT Estudo original Lipedema is a chronic adipose tissue disorder that may involve the upper extremities, particularly in advanced disease stages, leading to pain, heaviness, and functional complaints. While liposuction is an established treatment for symptom relief and volume reduction, its impact on objective upper-limb function-especially shoulder mobility-has not been systematically evaluated. A prospective observational cohort study was conducted in female patients with upper-extremity lipedema undergoing… https://lipedema360.com.br/artigos/42709932 https://lipedema360.com.br/artigos/42709932 Tue, 08 Sep 2026 12:00:00 GMT Estudo original This cross-sectional and descriptive study was conducted with 395 women to assess lipedema awareness, lipedema symptom levels, and the screening probability of lipedema. Data were collected using an Introduction Form, and the Questionnaire and Screening Model for Lipedema. The mean score on the lipedema screening questionnaire was 6.05 ± 4.58. It was determined that 15.4% of women had a high probability of developing lipedema. We found that participants demonstrated awareness regarding lipedema… https://lipedema360.com.br/artigos/42890093 https://lipedema360.com.br/artigos/42890093 Mon, 07 Sep 2026 12:00:00 GMT Estudo original The Questionário de avaliação sintomática do lipedema (QuASiL - Lipedema Symptom Assessment Questionnaire) assesses 13 distinct inflammatory symptoms of lipedema, but whether these symptoms resolve and recur simultaneously or follow a consistent order remains unknown. To characterize the persistence hierarchy of the 13 QuASiL inflammatory symptoms in a retrospective lipedema cohort under heterogeneous conservative treatment, using 6 complementary rank-order analyses and testing the null… https://lipedema360.com.br/artigos/42692034 https://lipedema360.com.br/artigos/42692034 Sat, 05 Sep 2026 12:00:00 GMT Ensaio clínico randomizado Lipoedema is a painful, chronic disease of the subcutaneous adipose tissue, predominantly affecting women. Conservative complex decongestive therapy is the standard of care but offers limited symptom relief. Liposuction appears to be a promising approach but lacks evidence of effectiveness and safety. The aim of this trial was to show superiority of liposuction compared with conservative therapy regarding relevant pain reduction with reasonable safety. In this multicentre, randomised controlled… https://lipedema360.com.br/artigos/42692026 https://lipedema360.com.br/artigos/42692026 Sat, 05 Sep 2026 12:00:00 GMT Estudo original https://lipedema360.com.br/artigos/42859491 https://lipedema360.com.br/artigos/42859491 Thu, 03 Sep 2026 12:00:00 GMT Revisão Lipedema is a chronic, progressive, and often underdiagnosed disease characterized by the pathological, bilateral, and symmetrical accumulation of adipose tissue. This distribution results in disproportionate and painful swelling of the limbs. Typically extending distally from the hips, this predominantly female condition is frequently misidentified as lifestyle-induced obesity or bilateral lymphedema. This review aims to provide a comprehensive overview of the current understanding of… https://lipedema360.com.br/artigos/42795335 https://lipedema360.com.br/artigos/42795335 Wed, 02 Sep 2026 12:00:00 GMT Estudo original Lipedema is a chronic progressive condition affecting approximately 10% of women, characterized by disproportionate subcutaneous adipose tissue accumulation and pain in the lower extremities. Standardized assessment methods for pain evaluation in lipedema remain limited. The Progressive Pain Check (PPC) method represents a potentially valuable tool for standardized pain assessment in lipedema patients. To evaluate the inter-rater reliability of the PPC method for clinical assessment of evoked… https://lipedema360.com.br/artigos/42824866 https://lipedema360.com.br/artigos/42824866 Tue, 01 Sep 2026 12:00:00 GMT Estudo original Lipedema is a common, female-predominant disorder characterized by disproportionate, painful lower-limb adipose tissue, and it still lacks an objective biomarker, a disease-modifying therapy, or consensus on whether its core lesion is inflammatory. Its molecular literature is openly contradictory, reporting both immune enrichment and immune down-regulation in the same gluteofemoral depot. Because the dominant morbidity is pain rather than adipose mass, this ambiguity carries direct clinical… https://lipedema360.com.br/artigos/42793248 https://lipedema360.com.br/artigos/42793248 Tue, 01 Sep 2026 12:00:00 GMT Revisão Lipedema and obesity are often misdiagnosed or clinically confused yet arise via distinct mechanisms, complicating diagnosis and treatment. This review synthesizes evidence differentiating these conditions across genetic, hormonal, inflammatory and mechanical pathways to identify therapeutic targets. Lipedema may involve genetic predisposition (forkhead box C2 [FOXC2], prospero homeobox 1 [PROX1]), hormonal dysregulation with aberrant aromatase activity, and altered adipogenesis (peroxisome… https://lipedema360.com.br/artigos/42740861 https://lipedema360.com.br/artigos/42740861 Mon, 31 Aug 2026 12:00:00 GMT Estudo original Lipedema is a chronic adipose tissue disorder characterized by bilateral and symmetrical subcutaneous fat accumulation, predominantly affecting women. Because it is frequently confused with obesity and lymphedema, diagnosis may be delayed. This proof-of-concept study aimed to evaluate the feasibility of LipoAssist, a structured GPT-4-based clinical workflow designed for the preliminary assessment of lipedema under simulated conditions. Ten simulated clinical scenarios representing lipedema and…