Lipedema diagnosis is heavily reliant on patient history. Various objective assessments have been suggested; however, a standardized measurement process is lacking. A systematic review was undertaken to identify which imaging and…
Eason HE et al. · Lymphatic research and biology · 5 mar 2025
This S2k guideline was developed on the initiative and under the German Society of Phlebology and Lymphology (DGPL) leadership. The guideline aims to optimize the diagnosis and treatment of lipedema. It is intended to bring…
Faerber G et al. · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 27 ago 2024
Diagnosing lipedema remains a challenge due to its heterogeneous presentation, co-existing diseases, and the lack of objective diagnostic imaging. This systematic review aims to outline the currently available diagnostic imaging…
van la Parra RFD, Deconinck C, Krug B · Obesity reviews : an official journal of the International Association for the Study of Obesity · 3 out 2023
Introduction Lipedema is a chronic, progressive condition that can result in considerable disability. In 2011, the Dutch Society of Dermatology and Venereology organized a task force to create guidelines on lipedema, using the…
Patient-relevant treatment benefit is traditionally measured with health-related quality of life (HRQoL) instruments. The Patient Benefit Index (PBI) methodology allows for a more direct measurement, with the patients rating both…
Blome C et al. · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 22 out 2013
ObjectivesLipedema is a progressive adipose disorder affecting women, with diagnosis often delayed due to symptom overlap and lack of validated tools. This study assesses the Turkish version of the Lipedema Screening…
IntroductionLipedema is a chronic adipose and connective tissue disorder in which pain is classically localized to affected limb tissue. However, some patients report joint, periarticular, myotendinous, or axial pain, with…
BackgroundChronic venous disorders and lipedema are complex and frequently underdiagnosed conditions characterized by heterogeneous clinical presentations, progressive tissue remodeling, and substantial variability in treatment…
ObjectivesLipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, lower extremity pain, functional impairment, and reduced quality of life. Although pain is a cardinal symptom, its…
Şahingöz Bakırcı E, Demir Karakılıç G · Phlebology · 16 out 2026
ObjectivesTo investigate the clinical and ultrasonographic changes associated with radial extracorporeal shock wave therapy (rESWT) in women with lipedema.MethodsThis prospective, single-arm study included 40 women with lipedema…
ObjectivesTo determine the prevalence of chronic venous insufficiency (CVI) in patients with lipedema, characterize venous reflux patterns and CEAP clinical classes, and evaluate associations with demographic and lipedema-related…
Gümrük Aslan S, Akın Yavuzel A, Gündoğdu O · Phlebology · 15 out 2026
There are no validated Norwegian disease-specific patient-reported outcome measures (PROMs) assessing quality of life (QoL) in females with lipedema, limiting evaluation of treatment effect in clinical practice and research. To…
Lundanes J et al. · Frontiers in global women's health · 9 out 2026
ObjectivesThis study aimed to determine the frequency of probable lipedema among women with lower extremity pain (LEP) using a validated screening questionnaire and to examine its associations with neuropathic pain (NP)…
Demir Karakılıç G et al. · Phlebology · 8 out 2026
Lipedema is a chronic adipose tissue disorder characterized by a disproportionate accumulation of painful subcutaneous fat on the extremities. Manual lymphatic drainage (MLD) is routinely used as therapeutic intervention, but its…
Nöll E et al. · Frontiers in cell and developmental biology · 7 out 2026
IntroductionAfter unification of diagnostic criteria for lipedema through guidelines and consensus documents as a fat-disproportion between abdomen and extremities with pain in the affected area, reduced by compression, expensive…
To comprehensively characterize pain in women with lipedema and evaluate its relationship with central sensitization, neuropathic pain characteristics, pain sensitivity, sleep quality, and quality of life. : A cross-sectional…
Orhan B et al. · Pain medicine (Malden, Mass.) · 12 set 2026
This cross-sectional and descriptive study was conducted with 395 women to assess lipedema awareness, lipedema symptom levels, and the screening probability of lipedema. Data were collected using an Introduction Form, and the…
Şimşekli D, Yağcı Karamanlı H, Doğan C · Health care for women international · 8 set 2026
Lipedema is a chronic, progressive, and often underdiagnosed disease characterized by the pathological, bilateral, and symmetrical accumulation of adipose tissue. This distribution results in disproportionate and painful swelling…
Nemes A · Reviews in cardiovascular medicine · 3 set 2026
Lipedema is a chronic progressive condition affecting approximately 10% of women, characterized by disproportionate subcutaneous adipose tissue accumulation and pain in the lower extremities. Standardized assessment methods for…
Patton L et al. · Life (Basel, Switzerland) · 2 set 2026
Lipedema is a chronic adipose tissue disorder characterized by bilateral and symmetrical subcutaneous fat accumulation, predominantly affecting women. Because it is frequently confused with obesity and lymphedema, diagnosis may…
Yukselmis O et al. · Frontiers in medicine · 31 ago 2026
Hyperechoic subcutaneous nodules in lipedema may mimic angiolipomas but represent an inflammatory and hypoxic-ischemic process rather than a neoplasia, despite tissue expansion. As the painful nodules expand, biopsy is…
ObjectiveThis study aimed to investigate central sensitization (CS) in individuals with lipedema using pressure pain threshold measurements and to examine its relationship with clinical features, sonographic findings, body…
Yücel FN, Candan Z, Ata E · Phlebology · 18 ago 2026
To evaluate ultrasonographic changes in lower extremity tendons and plantar fascia of patients with chronic edema and their relationship with edema volume, pain, function, and quality of life. This observational case-control…
Uğur AE, Soyupek F, Özçakar L · American journal of physical medicine & rehabilitation · 11 ago 2026
Lipedema is a chronic disorder characterized by excessive, bilateral, and symmetrical deposition of subcutaneous adipose tissue, predominantly in the lower extremities. Despite its prevalence, lipedema is frequently misdiagnosed…
Mortada H et al. · Plastic and reconstructive surgery. Global open · 10 ago 2026
Lipedema is a chronic progressive disease characterized by disproportionate and symmetric adipose tissue accumulation, predominantly affecting women, with upper extremity involvement (Type IV) in approximately 30% of cases. This…
We aimed to evaluate the association between pain, body mass index (BMI), clinical stage, and morphological type in women with lipedema, using segmental bioimpedance to correlate with clinical symptoms. We conducted a…
Pusic J, Mora S, Froes Meyer P · Journal of vascular surgery. Venous and lymphatic disorders · 24 jul 2026
ObjectivesThere is a deficiency in awareness and knowledge of lipedema disease among the general public and healthcare professionals. This situation may lead patients to waste time on getting the correct diagnosis and treatment.…
Candan Z, Yücel FN, Ata E · Phlebology · 25 jun 2026
Lipedema is a chronic adipose tissue condition that primarily affects women. Despite increasing recognition of lipedema, the condition remains poorly understood and lacks standardized diagnostic criteria or confirmatory tests.…
Galia S et al. · Frontiers in global women's health · 24 jun 2026
Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat deposition, pain, and progressive functional impairment. Although diagnosis remains primarily clinical, ultrasound has emerged as a valuable…
Bruno A et al. · Aesthetic plastic surgery · 19 jun 2026
Lipedema is a chronic condition that is often underdiagnosed. Clinical overlap with other disorders and the absence of specific diagnostic tools may delay diagnosis. This study aimed to translate and culturally adapt the lipedema…
Mansız-Kaplan B, Yaman A · Turkish journal of physical medicine and rehabilitation · 10 jun 2026
ObjectiveLipedema, which mainly affects women, is a chronic and progressive disorder characterized by abnormal adipose tissue accumulation in the limbs. Despite its clinical importance, research on lipedema remains limited.…
Çetin Duru E, Koçyiğit BF · Phlebology · 10 jun 2026
ObjectivesLipedema is a chronic disorder characterized by pain and disproportionate fat distribution, and its diagnosis is frequently overlooked. The aim of this study was to evaluate and compare the responses generated by…
BackgroundLipedema is an adipose disorder associated with multiple impairments. Conservative treatments remain the mainstay of management, yet evidence regarding the effects of physical therapies on clinical, imaging, and body…
BackgroundLipedema is a chronic and progressive disorder of subcutaneous adipose tissue that predominantly affects women and is frequently misdiagnosed as obesity, lymphedema, or venous disease. Increasing evidence indicates that…
BackgroundLipedema is a chronic, progressive adipose tissue disorder affecting mainly women, characterized by bilateral, disproportionate fat accumulation in the lower extremities. The condition is often associated with pain,…
Ozbek IC, Kuculmez O, Dundar Ahi E · Phlebology · 8 mai 2026
Lipedema is a painful subcutaneous adipose tissue (SAT) disorder that mainly affects women. Patients present fat accumulation in the limbs, especially in the legs. A pilot-controlled clinical trial was conducted on a sample of 18…
Úbeda-D'Ocasar E et al. · Journal of bodywork and movement therapies · 25 abr 2026
BACKGROUND/OBJECTIVES: Lipedema is a chronic and progressive adipose tissue disorder characterized by the abnormal accumulation of subcutaneous fat, predominantly in the legs and occasionally in the arms. The symptom that most…
Yaman A, Mansız-Kaplan B · International journal of obesity (2005) · 14 mar 2026
Lower extremity edema results from an imbalance between capillary hydrostatic pressure, oncotic pressure, and lymphatic drainage, leading to fluid accumulation in the interstitial space. Most cases are bilateral, typically due to…
Greenberg J, Greenberg J, Laurie A · FP essentials · 1 mar 2026
ObjectivesThis study aimed to analyze the complex components of pain in lipedema and to evaluate correlations among key pain-related parameters, including intensity, hypersensitivity, catastrophizing, central sensitization, and…
ObjectiveTo evaluate the educational quality, reliability, and transparency of YouTube™ videos on lipoedema, and to examine associations with uploader type and engagement metrics.MethodsOn 15 May 2025 we searched YouTube™ for…
Lipoedema is a condition of abnormal accumulation of painful adipose tissue, usually in the lower body of women. The disproportionate subcutaneous adipose tissue may negatively impact health-related quality of life (HRQoL). There…
Stellmaker R et al. · Journal of psychosomatic research · 2 fev 2026
Lipedema predominantly affects women and is characterized by an abnormal distribution of adipose tissue, accompanied by pain or discomfort in affected areas. Despite growing awareness, inconsistent diagnostic criteria and…
Kruppa P et al. · Nature communications · 10 jan 2026
Lipedema is a chronic adipose tissue disorder that primarily affects women, characterized by symmetrical and disproportionate fat accumulation in the lower and/ or upper extremities, sparing hands and feet. This review aims to…
Background/Objectives: Lipedema is a chronic, progressive adipo-fascial disorder characterized by connective tissue dysfunction, fibrosis, microangiopathy, and adipose tissue proliferation. Although lipedema has traditionally…
Fiengo E, Sbarbati A · Journal of clinical medicine · 18 dez 2025
Lipedema is a chronic adipose tissue disorder primarily affecting women, marked by abnormal, symmetrical, and disproportionate accumulation of subcutaneous fat in the lower limbs and sometimes in the arms, with hands and feet…
Kuttiatt VS et al. · Journal of postgraduate medicine · 10 dez 2025
Lipedema is a relatively unknown condition, often leading to misdiagnosis and a lack of proper treatment. To explore the experiences of seeking healthcare support and treatment among women with a physician-verified diagnosis of…
Dahlberg J et al. · International journal of women's health · 27 nov 2025
Aim Lipedema is a chronic, progressive disease that predominantly affects women and is strongly influenced by estrogen. Its onset or worsening is associated with hormonal periods such as puberty, pregnancy, pregnancy induction,…
The etiology of lipoedema remains unclear, making diagnosis and treatment challenging. Current treatment primarily consists of general lifestyle recommendations, with effective self-management being essential for integrating…
Kloosterman LM et al. · Journal of multidisciplinary healthcare · 26 set 2025
Background: Lipedema, a chronic condition affecting mostly women, involves painful bilateral increase of subcutaneous adipose tissue. The societal impact of this disease is still poorly understood. This study aimed to validate…
Mahler J et al. · Lymphatic research and biology · 25 set 2025
Lipedema is a chronic disorder of adipose tissue that predominantly affects women and is frequently misdiagnosed as obesity or lymphedema. Traditionally associated with the lower extremities, lipedema can also involve the…
Bruno A, Cilluffo M · Aesthetic plastic surgery · 12 set 2025
Lipedema is a chronic, progressive adipose connective tissue disorder characterized by symmetrical, disproportionate fat accumulation, typically affecting the lower extremities and arms, accompanied by pain, swelling, and a…
Al-Ghadban S et al. · Life (Basel, Switzerland) · 3 set 2025
To identify research priorities related to the diagnosis, treatment and management of lipoedema. This was a research question priority-setting that ensured the involvement of patients, relatives and healthcare professionals in…
ObjectiveThe incidence of lipedema is poorly described due to its confusion with lymphedema. Patient education is crucial for treatment and prevention strategies but also for improving healthcare outcomes. This study assessed and…
Lipoedema (lipalgia) is a condition that is often underdiagnosed or misdiagnosed as obesity or lymphoedema, which can result in mismanagement of treatment leading to poor mental and physical outcomes. It is a condition that is…
Crouch M · British journal of nursing (Mark Allen Publishing) · 7 ago 2025
ObjectiveTo assess the relationship between disease severity in lipedema and tissue stiffness measured using shear wave elastography (SWE) concerning pain threshold and quality of life as well as determine differences in…
BackgroundTo evaluate kinesiophobia and its relationship with disease-related characteristics and quality of life in lipedema patients.MethodsIn this descriptive case-control study, 40 lipedema patients and 40 participants in the…
Lipedema is a chronic adipose tissue disorder traditionally considered to affect almost exclusively women, with recent estimates suggesting approximately 0.2% prevalence in men worldwide; the condition remains underdiagnosed in…
Background: Pain is a prevalent symptom in patients with lipedema predominantly impacting the lower extremities. This study aimed to evaluate the relationship between 25-hydroxyvitamin D [25(OH)D] and vitamin B12 levels and…
Ozturk G et al. · Lymphatic research and biology · 16 abr 2025
Lipoedema is a loose connective tissue disease primarily affecting women characterized by an abnormal build-up of painful fat in the legs and arms. In healthcare, lipoedema is often confused with obesity, and today, diagnostic…
IntroductionLipedema is a chronic and progressive adipose tissue disorder that predominantly affects women. However, despite its high prevalence and severe negative impact on quality of life, it remains significantly…
Lipalgia syndrome, also known as lipoedema, is a chronic condition involving disproportionate adipose tissue accumulation with pain and tenderness. This study explores the perceptions, challenges and needs of lymphoedema…
Cooper G et al. · British journal of community nursing · 1 abr 2025
Lipedema diagnosis is heavily reliant on patient history. Various objective assessments have been suggested; however, a standardized measurement process is lacking. A systematic review was undertaken to identify which imaging and…
Eason HE et al. · Lymphatic research and biology · 5 mar 2025
The cause of lipoedema remains unclear, and the condition is currently incurable. Effective self-management is therefore essential for coping with its physical and psychological impacts and the necessary lifestyle adjustments.…
Kloosterman LM et al. · Journal of multidisciplinary healthcare · 27 fev 2025
ObjectivesTo evaluate the presence of lipedema and lipedema-related factors in fibromyalgia patients.MethodsThe study included 100 female patients over the age of 18 who met the fibromyalgia diagnostic criteria. The patients were…
Bolkan Günaydın E et al. · Phlebology · 14 fev 2025
Lipedema, historically underrecognized, has recently gained attention due to advancements in research and growing public awareness. The Brazilian Consensus Statement on Lipedema, developed by the Brazilian Society of Angiology…
Amato ACM et al. · Jornal vascular brasileiro · 10 fev 2025
Background: Lipedema is a chronic condition characterized by abnormal deposition of subcutaneous adipose tissue, leading to pain. The lack of internationally recognized diagnostic criteria complicates the characterization of…
Bettariga F et al. · Lymphatic research and biology · 24 dez 2024
This study addresses the diagnostic challenges of identifying lymphoedema in patients with lipoedema using lymphoscintigraphy. Overdiagnosis of lymphoedema in this patient population is frequent and may result in reduced proposed…
Lower limb swelling presents a diagnostic challenge with diverse causes, including well-known issues like venous insufficiency and lymphedema, and less-understood conditions like lipedema. Lipedema, involving abnormal fat…
Alosaimi K, Mortada H, Alshomer F · Plastic and reconstructive surgery. Global open · 18 set 2024
This S2k guideline was developed on the initiative and under the German Society of Phlebology and Lymphology (DGPL) leadership. The guideline aims to optimize the diagnosis and treatment of lipedema. It is intended to bring…
Faerber G et al. · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 27 ago 2024
Body composition (BC) measured by DXA differs between devices. We aimed to compare regional and total BC measurements assessed by the Hologic Horizon A and the GE Lunar iDXA devices; to determine device-specific calibration…
The role of artificial intelligence (AI) in healthcare is evolving, offering promising avenues for enhancing clinical decision making and patient management. Limited knowledge about lipedema often leads to patients being…
Leypold T et al. · Life (Basel, Switzerland) · 20 mai 2024
Lipedema is a widespread severe chronic disease affecting mostly women. Characterized by painful bilateral fat accumulation in extremities sparing hands and feet, objective measurement-based diagnosis is currently missing. We…
Lipoedema is the disproportionate accumulation of adipose tissue in the lower body, often associated with hormonal changes in women. Lipoedema is commonly misdiagnosed as lymphoedema or obesity due to similarities in appearance.…
Stellmaker R et al. · Clinical obesity · 28 mar 2024
Lower extremity swelling may be broadly characterized as due to edema, lymphedema, or lipedema. Differentiation between these three conditions is important for providing appropriate treatment. This review analyzes and compares…
Lipedema is a chronic disease marked by symmetric enlargement of painful nodular and fibrotic adipose tissue, predominantly affecting the limbs. Since there is no specific test or biomarker for this condition, years often pass…
Kempa S et al. · Clinical hemorheology and microcirculation · 1 jan 2024
Symmetrical bilateral lower extremity edema (BLEE) needs to be treated effectively. Finding the cause of this condition increases the success of treatment. Fluid increase in the interstitial space (FIIS) is always present as a…
Ceylan S, Yilmaz N · Current medical imaging · 1 jan 2024
Lipedema is a chronic condition characterized by disproportionate and symmetrical enlargement of adipose tissue, predominantly affecting the lower limbs of women. This study investigated the use of metabolomics in lipedema…
Kempa S et al. · International journal of molecular sciences · 13 dez 2023
To quantify and compare associations and relationships between self-rated and tested assessments of mainly mobility-related physical function in different diagnoses. Six longitudinal cohort studies before and after inpatient…
Benz T et al. · Journal of rehabilitation medicine · 4 dez 2023
Diagnosing lipedema remains a challenge due to its heterogeneous presentation, co-existing diseases, and the lack of objective diagnostic imaging. This systematic review aims to outline the currently available diagnostic imaging…
van la Parra RFD, Deconinck C, Krug B · Obesity reviews : an official journal of the International Association for the Study of Obesity · 3 out 2023
One of the most common reasons for patient visits in the outpatient practice is lower extremity swelling. Non-cardiac etiologies are the most frequent reason for these encounters. The approach to this patient population will…
Merli GJ, Yenser H, Orapallo D · The Medical clinics of North America · 1 set 2023
The pathologic features of fatty tissue in lipedema are often challenging to diagnose, thus allowing for variable bias and leading to underdiagnosis. Lipedema is a disease that is currently little known worldwide, but it…
Carballeira Braña A, Poveda Castillo J · International journal of environmental research and public health · 25 ago 2023
Background: The presence of edema in patients with lipedema has been investigated in many studies. However, no study has been found that examines the amount of intracellular (ICF) and extracellular fluid (ECF) in these patients…
Esmer M, Schingale FJ · Lymphatic research and biology · 2 ago 2023
Lipohyperplasia dolorosa, also known by the misnomer "lipedema", is a clinical picture first described more than 80 years ago, that in the last 25 years has received increasing attention in medical practices, but also…
Cornely ME · Dermatologie (Heidelberg, Germany) · 17 jul 2023
A large and growing body of research suggests that the skin plays an important role in regulating total body sodium, challenging traditional models of sodium homeostasis that focused exclusively on blood pressure and the kidney.…
Chattopadhyay A et al. · Clinical and experimental dermatology · 7 jul 2023
Lipedema is a loose connective tissue disease characterized by a disproportionate accumulation of adipose tissue in the limbs of women. Despite its incidence of 10-20%, lipedema is often underdiagnosed and misdiagnosed. This…
van la Parra RFD et al. · Journal of plastic, reconstructive & aesthetic surgery : JPRAS · 30 mai 2023
Lipedema is a painful subcutaneous adipose tissue (SAT) disease involving disproportionate SAT accumulation in the lower extremities that is frequently misdiagnosed as obesity. We developed a semiautomatic segmentation pipeline…
Taylor SL et al. · Journal of medical imaging (Bellingham, Wash.) · 15 mai 2023
Lipoedema is an adipose tissue disorder almost exclusively affecting women. Evidence shows lipoedema is both poorly recognised and misdiagnosed which results in many women struggling to get a diagnosis and to gain access to…
Warrilow M · British journal of community nursing · 1 abr 2023
Background: To define the usefulness of three-dimensional (3D) ultrasound diagnostics for lipedema. Methods and Results: In this study, starting in May 2021, it was decided to apply 3D ultrasound diagnostics in the evaluation of…
Cestari M · Lymphatic research and biology · 28 mar 2023
Expert representatives from 11 professional societies, as part of an autonomous work group, researched and developed appropriate use criteria (AUC) for lymphoscintigraphy in sentinel lymph node mapping and lymphedema. The…
Donohoe KJ et al. · Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 23 mar 2023
The lymphatics play important roles in chronic diseases/conditions that comprise the bulk of healthcare worldwide. Yet the ability to routinely image and diagnose lymphatic dysfunction, using commonly available clinical imaging…
Sevick-Muraca EM, Fife CE, Rasmussen JC · Frontiers in physiology · 15 mar 2023
Lipoedema is characterized by disproportionate painful fat accumulation mostly in the lower limbs. The presence of lymphoedema in lipoedema remains controversial. This study aimed to assess the presence or absence of lymphoedema…
Lipoedema is a painful non-pitting diffuse "fatty" swelling, usually confined to the legs, that occurs mainly in women. This scoping review aimed to provide an overview of the available research on the functioning of people with…
Kloosterman LM et al. · International journal of environmental research and public health · 21 jan 2023
Lipoedema is an overlooked and often misdiagnosed condition, which mainly affects women. This review summarises the present knowledge of the condition. It is characterised by bilateral and symmetrical accumulation of subcutaneous…
Andersen MT et al. · Ugeskrift for laeger · 19 dez 2022
Edema of the lower extremities is always associated with a pathological condition that should be treated, especially in patients with chronic wounds. Because the underlying causes of edema can vary greatly and sometimes be…
Stücker M et al. · Dermatologie (Heidelberg, Germany) · 9 dez 2022
Lipedema is a poorly known condition. Diagnosis is based almost exclusively on clinical criteria, which may be subjective and not always reliable. This study aimed to investigate regional body composition (BC) by dual-energy…
The aim of this study was to define outcomes after total knee arthroplasty (TKA) in lymphoedema and lipoedema patients managed by a multidisciplinary team and daily compression bandaging. A retrospective study was performed in a…
Granger L et al. · International orthopaedics · 8 set 2022
The lipedematous scalp (LS) is characterized by a thickened scalp because of the increased thickness of the subcutaneous fat layer. When the soft and boggy scalp is associated with shortened hairs and hair loss, it is referred to…
Hu D, Yang S · The American Journal of dermatopathology · 1 set 2022
To contribute to a more in-depth assessment of shape, volume, and asymmetry of the lower extremities in patients with lipedema or lymphedema utilizing volume information from MR imaging. A deep learning (DL) pipeline was…
Background: Lipedema of lower limbs is characterized by bilateral accumulations of excess adipose tissue starting from the ankle to the hips and buttocks. The studies with lymphoscintigraphy (LSC) and magnetic resonance (MR)…
Zaleska MT, Olszewski WL, Krzesniak NE · Lymphatic research and biology · 8 jun 2022
Lower extremity edema is a common complaint of patients across all medical specialties. This is a wide group of conditions, ranging from relatively minor conditions such as false swelling in lipedema to life-threatening…
Lipedema is a chronic and progressive disease associated with lymphatic impairment at later stages. The aim of our study was to describe the functional status and anatomy of lower limb superficial lymphatic system using…
Buso G et al. · Microvascular research · 9 dez 2021
To examine the common and specific characteristics of fibromyalgia and lipedema, two chronic soft-tissue pain syndromes without curative therapy options. Diseases' characteristics were compared using the findings of extensive…
Angst F et al. · Journal of pain research · 17 set 2021
Lipedema is characterized by the deposition of abnormal fat in the lower and upper limbs bilaterally. It is a disease with high prevalence and genetic characteristics. Non-specific and non-quantified increases in the thickness of…
Background: Lymphatic disease patients make up a significant proportion of the US and world populations. Due to inadequate medical school training and underestimation of the impact of lymphatic circulation, lymphatic disease…
Chang D et al. · Lymphatic research and biology · 5 fev 2021
Lipedema is a chronic and progressive disease. Most studies agree that it is underdiagnosed and undertreated. The aim of this study was to identify the diagnostic characteristics and types of treatment for lipedema in the Spanish…
Vaquero Ramiro E et al. · Rehabilitacion · 15 jan 2021
Lipedema is greatly underdiagnosed and there is a lack of low-cost tools to facilitate diagnostic. We created a lipedema screening questionnaire based on a questionnaire for assessing symptoms. The study objectives were to…
Amato ACM et al. · Jornal vascular brasileiro · 11 dez 2020
Lipedema is a widespread in concern of etiology partially unknown disease especially in women. In many cases it is accompanied by bleeding complications. Our current work focuses on possible coagulation disorders as potential…
Lipedema is characterized as abnormal bilateral deposition of fat in the buttocks and legs that may be accompanied by orthostatic edema in women. A questionnaire for assessment of lipedema symptoms has previously been published…
Amato ACM et al. · Jornal vascular brasileiro · 31 ago 2020
Lipedema is characterized by pain, fatigue, and excessive adipose tissue and sodium accumulation of the lower extremities. This case-control study aims to determine whether sodium or vascular dysfunction is present in the central…
To assess imaging findings and characteristics of the lymphatic system in patients affected by lipedema and lipolymphedema of the lower extremities on Non-Contrast MR Lymphography (NCMRL). 44 lower extremities in 11 consecutive…
Cellina M et al. · Magnetic resonance imaging · 17 jun 2020
Lipedema is often unrecognized or misdiagnosed; despite an estimated prevalence of 10% in the overall female population, its cause is still unknown. There is increasing awareness of this condition, but its differential diagnosis…
Kruppa P et al. · Deutsches Arzteblatt international · 1 jun 2020
Lipedematous scalp is an uncommon entity of unknown etiology, rarely described in the pediatric age. It is characterized by boggy thickening of the scalp predominantly located at the vertex and occiput, which acquires a…
Míguez-Martín L et al. · Dermatology online journal · 15 mai 2020
The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). MRI was performed at 3.0 T in females with…
Crescenzi R et al. · Obesity (Silver Spring, Md.) · 9 abr 2020
Lipedema is a fat disorder that is often misdiagnosed. It was first identified at the Mayo Clinic in 1940, but medical schools do not include it in their curriculum and is therefore poorly understood. It presents as…
Caruana M · Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses · 1 jan 2020
Lipedema is a chronic progressive disease characterized by abnormal fat distribution resulting in disproportionate, painful limbs. It almost exclusively affects women, leading to considerable disability, daily functioning…
Buso G et al. · Obesity (Silver Spring, Md.) · 1 out 2019
Although lipedema is often clinically distinguished from lymphedema, there is considerable overlap between the two entities. The purpose of this study was to evaluate lymphoscintigraphic findings in patients with lipedema to…
Gould DJ et al. · Journal of reconstructive microsurgery · 23 set 2019
640 patients from a specialist clinic for operative lymphology were surveyed with the help by a questionnaire issued by the German Society of Pain Therapy (Deutsche Schmerzgesellschaft e. V.). This survey collected responses to…
Gensior MHL, Cornely M · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 14 ago 2019
Three-dimensional surface imaging (3DSI) has proven to be useful in providing objective aid to the planning process and documentation of various plastic-surgical procedures. Although this technology is routinely used in the…
Etzel L et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 14 ago 2019
Background: Lipedema and Dercum's disease (DD) are incompletely characterized adipose tissue diseases, and objective measures of disease profiles are needed to aid in differential diagnosis. We hypothesized that fluid properties,…
Crescenzi R et al. · Lymphatic research and biology · 13 ago 2019
Tehler M, Bergert P · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 8 jan 2019
Tape measures continue to be used for the diagnosis and evaluation of lipoedema and lymphoedema in the clinical routine. Extremity volumes are calculated based on standardised circumferential measurements. Other volume…
Koban KC et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 8 jan 2019
Lipoedema is a progressive disease, which predominantly affects women. It is characterised by circumferential growth, with increase in fat tissue of the extremities, and can lead to oedema. In contrast, the lymphoedema is defined…
Zetzmann K et al. · Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V... · 8 jan 2019
Lipoedema is a chronic disorder of adipose tissue, characterised by disproportionate fat deposits in the lower limbs and pain with preservation of the feet. The condition usually only affects women. Diagnosis is clinical and…
Redondo Galán C, García Bascones M, Marquina Valero MA · Rehabilitacion · 1 jan 2019
Unilateral lower extremity edema below the knee commonly results from deep venous thrombosis, venous insufficiency, or lymphedema. The patient history, a physical examination, and lower extremity venous duplex ultrasound often…
Mutluer FO et al. · Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir · 1 dez 2018
Chronic lymphoedema (CLE) is a burdensome disease of multiple causes leading to significant reductions in health-related quality of life (HRQoL). A specific method to assess HRQoL is the Freiburg Life Quality Assessment for…
Augustin M et al. · The British journal of dermatology · 5 out 2018
Lipoedema is painful nodular subcutaneous adipose tissue (SAT) on legs and arms of women sparing the trunk. People with Dercum disease (DD) have painful SAT masses. Lipoedema and DD fat resists loss by diet and exercise.…
Lipedema is a syndrome that is characterised by edema, an accumulation of fat, pain and haematomas in the lower limbs that principally affects women. Diagnosis is currently based on clinical criteria, since there is no accurate…
Forner-Cordero I et al. · Revista espanola de medicina nuclear e imagen molecular · 28 ago 2018
Lipoedema is a rare painful disorder of the adipose tissue. It essentially affects females and is often misdiagnosed as lymphoedema or obesity. It is globally misdiagnosed or underdiagnosed, and the literature is lacking…
Shavit E, Wollina U, Alavi A · International wound journal · 29 jun 2018
Implementation of guideline recommendations for the diagnosis and therapy of lipedema and lymphedema seems to be problematic in daily routine. Systematic data for Germany are missing. The aim of the study was data collection…
Reich-Schupke S, Mohren E, Stücker M · Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 1 jun 2018
Lipedema is a fat disorder that is often misdiagnosed. It was first identified at the Mayo Clinic in 1940, but medical schools do not include it in their curriculum and is therefore poorly understood. It presents as…
Caruana M · Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses · 1 jan 2018
Lipedema: Which Etiological Pathways? Abstract. The pathogenesis and epidemiology of lipedema are uncertain, and its diagnosis often delayed. Lipedema almost exclusively affects women, and a link to sex hormones is likely. The…
Lipedema, the Unknown Abstract. Lipoedema patients suffer from the widespread ignorance of their pathology. Considering its chronic, progressive and invalidating character, the early diagnosis of the disease must constitute the…
To test the hypothesis that tissue sodium and adipose content are elevated in patients with lipedema; if confirmed, this could establish precedence for tissue sodium and adipose content representing a discriminatory biomarker for…
Crescenzi R et al. · Obesity (Silver Spring, Md.) · 27 dez 2017
Lipedematous scalp, with or without alopecia, is a poorly known and rarely reported entity. It was first described in 1935 by Cornbleet. It involves increased thickness of the subcutaneous tissue of the scalp, responsible for an…
Chaplain L et al. · Annales de dermatologie et de venereologie · 16 out 2017
Lower extremity edema is extremely common among patients seen across multiple specialties. The differential diagnosis is broad and ranges from simple dependent edema to more complex conditions such as chronic venous disease and…
Ratchford EV, Evans NS · Current treatment options in cardiovascular medicine · 1 mar 2017
People with lipedema or Dercum's disease (DD) can have a similar distribution of excess painful nodular subcutaneous adipose tissue (SAT), making them difficult to differentiate. Case series of 94 patients with DD, 160 with…
Beltran K, Herbst KL · International journal of obesity (2005) · 18 nov 2016
Lipoedema is a chronic progressive adipose disorder that affects mainly women and presents as symmetrical enlargement of the buttocks and legs. It is commonly misdiagnosed as obesity or lymphoedema, but careful assessment will…
Todd M · British journal of community nursing · 1 out 2016
Lipedema is an uncommon disorder characterized by localized adiposity of the lower extremities, often occurring in females with a family history of the condition. The adiposity extends from hips to ankles and is typically…
Warren Peled A, Kappos EA · International journal of women's health · 11 ago 2016
Introduction Lipedema is a chronic, progressive condition that can result in considerable disability. In 2011, the Dutch Society of Dermatology and Venereology organized a task force to create guidelines on lipedema, using the…
Women wait decades for an accurate diagnosis of lipoedema. Earlier diagnosis is essential to prevent the condition progressing to lymphoedema, with its risk of life-threatening cellulitis.
Mason M · Nursing standard (Royal College of Nursing (Great Britain) : 1987) · 8 jul 2015
Frequently misdiagnosed as obesity, lipoedema is chronic condition involving an abnormal build-up of fat cells in the legs, thighs and buttocks that cannot be shifted by exercise or dieting. Estimated to affect up to 11% of the…
Fetzer A, Fetzer S · British journal of community nursing · 1 abr 2015
Application of microcurrents of bioresonance may allow protein aggregates lysis and a related enhancement of lymphatic drainage. Combining bioresonance with transcutaneous passage of active principles, by means of skin…
Elio C et al. · Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia · 1 dez 2014
Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and…
Pavlov-Dolijanovic SR et al. · Rheumatology international · 1 mai 2014
Distinguishing lymphoedema from lipoedema in women with swollen legs can be difficult. Local tissue water content can be quantified using tissue dielectric constant (TDC) measurements. To examine whether TDC measurements can…
Birkballe S et al. · The British journal of dermatology · 1 jan 2014
Leg swelling is an extremely frequent symptom with a broad variety of largely differing causes. The most important mechanisms behind the symptom include venous and lymphatic pathology, volume overload, increased capillary…
Patient-relevant treatment benefit is traditionally measured with health-related quality of life (HRQoL) instruments. The Patient Benefit Index (PBI) methodology allows for a more direct measurement, with the patients rating both…
Blome C et al. · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 22 out 2013
A grossly obese woman was wrongly diagnosed throughout her adult life of having lymphoedema. Her condition was subsequently confirmed as lipoedema, an entirely different condition, which is noted in medical text books but is…
Goodliffe JM et al. · BMJ case reports · 24 mai 2013
Lipoedema UK was founded in 2012 by women with lipoedema and clinicians working in the Lymphoedema Service at St George's Hospital in London. Its patron is Professor Peter Mortimer, the UK's leading Lipoedema expert, and its…
Evans S · British journal of community nursing · 1 abr 2013
Functional pelvic disorders in patients undergoing conservative surgical approach for rectal cancer are considered a major public health issue and represent one third of cost of colorectal cancer. We investigated the hypothesis…
Vannelli A et al. · European review for medical and pharmacological sciences · 1 abr 2013
Due to its increased presence in the press and on television, the diagnosis of lipedema is on the way to becoming a trendy diagnosis for those with thick legs. Despite this, one must recognize that lipedema is a very rare…
Reich-Schupke S, Altmeyer P, Stücker M · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 11 dez 2012
Lipedema is a disproportionate, symmetrical fatty swelling characterized by pain and bruising existing almost exclusively among women. We undertook a systematic review of the available literature about lipedema, given the lack of…
Forner-Cordero I et al. · Clinical obesity · 3 ago 2012
Lipedema is a clinical entity frequently misdiagnosed or confound with primary lymphedema. Lipedema is a disorder of adipose tissue that occurs almost exclusively in obese women. It is characterized by bilateral enlargement from…
Vignes S · Journal des maladies vasculaires · 13 jun 2012
DEFINITION AND CLINICAL PICTURE: We propose the minimal definition of Dercum's disease to be generalised overweight or obesity in combination with painful adipose tissue. The associated symptoms in Dercum's disease include fatty…
Hansson E, Svensson H, Brorson H · Orphanet journal of rare diseases · 30 abr 2012
Lipedema is a chronic disease of lipid metabolism that results in the symmetrical impairment of fatty tissue distribution and storage combined with the hyperplasia of individual fat cells. Lipedema occurs almost exclusively in…
Shin BW et al. · Annals of rehabilitation medicine · 30 dez 2011
There are many causes for a large lower limb in the pediatric age group. These children are often mislabeled as having lymphedema, and incorrect diagnosis can lead to improper treatment. The purpose of this study was to determine…
Schook CC et al. · Plastic and reconstructive surgery · 1 abr 2011
Unclear extremity complaints are common symptoms of inpatients. In a subset of these patients, a clinical suspicion of deep vein thrombosis (DVT) results; this needs to be quickly and definitively clarified by a vascular…
Taute B, Melnyk H, Podhaisky H · Medizinische Klinik (Munich, Germany : 1983) · 28 set 2010
Lipedema is an underdiagnosed syndrome of unclear etiology, characterized by symmetric painful enlargement of the buttocks and lower extremities, which spares the feet. This enlargement is caused by the deposition of adipose…
Pascucci A, Lynch PJ · Dermatology online journal · 15 set 2010
Adiposis dolorosa (AD) is a rare disorder of painful nodular subcutaneous fat accompanied by fatigue, difficulty with weight loss, inflammation, increased fluid in adipose tissue (lipedema and lymphedema), and hyperalgesia.…
Herbst KL, Rutledge T · Journal of pain research · 20 ago 2010
Lipoedema is an accumulation of fat abnormally distributed in the lower limbs, and lymphoedema is oedema caused by a deficiency of the lymphatic system. High-resolution ultrasound operating at 20 MHz makes it possible to…
Naouri M et al. · The British journal of dermatology · 16 abr 2010
To enhance the learner's competence in caring for patients with lipedema through understanding the differential diagnoses, pathophysiology, and treatment/management options. This continuing education activity is intended for…
Fife CE, Maus EA, Carter MJ · Advances in skin & wound care · 1 fev 2010
Lipoedema is an infrequently recognized disorder in women. Lipoedema is characterized by bilateral enlargement of the legs due to abnormal depositions of subcutaneous fat associated with often mild oedema. There is substantial…
Langendoen SI et al. · The British journal of dermatology · 20 jul 2009
Lipofibromatosis is a slow-growing, childhood soft-tissue neoplasm that is often confused with other conditions. We report a patient with lipofibromatosis causing extremity enlargement at birth. The lesion initially was thought…
Greene AK et al. · Annals of plastic surgery · 1 jun 2009
Lipedema is characterized by symmetric lower extremity enlargement secondary to the deposition of fat. Lipedema is not rare, but it is commonly misdiagnosed as lymphedema. We describe a 20-year-old woman with massive lower…
Fonder MA, Loveless JW, Lazarus GS · Journal of the American Academy of Dermatology · 1 ago 2007
This paper provides the results of examination of 413 patients aged 15 to 79 years (mean age 43.2 years) with different stages of CVI seen from 1995 to 2005. A complex of methods was employed: the clinical nmltimodality…
Tsukanov IT, Tsukanov AI · Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery · 1 jan 2007
Many investigations and treatments exist for lower limb lymphoedema. We undertook a survey on the management of this condition by vascular surgeons and the resources available for its treatment in the UK. A questionnaire was…
Tiwari A, Myint F, Hamilton G · European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 1 dez 2005
Lipedema refers to the abnormal deposition of subcutaneous fat causing a striking enlargement of the lower extremities that is out of proportion to the upper body. Most clinicians are unaware of this disease and thus it is seldom…
Koss T et al. · Journal of the American Academy of Dermatology · 1 jun 2004
Both generalized and localized edema needs to be submitted to a differential diagnostic investigation. In the case of edema affecting the lower extremities, in particular the Stemmer sign which is the inability to tent the skin…
Fries R · MMW Fortschritte der Medizin · 15 abr 2004
Painful fat syndrome or lipoedema is a distinct clinical condition, characterised by bilateral and symmetrical enlargement of the upper and lower leg with tenderness, but excluding the feet. Lipoedema occurs almost exclusively in…
Chen S et al. · British journal of plastic surgery · 1 abr 2004
The causes and management of lower limb lymphedema in the Western population are different from those in the developing world. To look at the differential diagnosis, methods of investigation, and available treatments for lower…
Tiwari A et al. · Archives of surgery (Chicago, Ill. : 1960) · 1 fev 2003
Methods for lymphatic imaging are numerous and can be roughly classified as anatomic or functional studies. Direct or indirect lymphographies provide useful informations in case of lymphostasis. Contrast lymphangiography is the…
Pecking AP, Desprez-Curely JP, Cluzan RV · La Revue de medecine interne · 1 jun 2002
Lipedema represents a form of lipodistrophy, which consists of abnormal accumulation of fat in subcutaneous tissue of the lower limbs with consecutive development of lymphostasis and lymphedema. The aim of this article was to…
Ignjatović M, Cerović S · Vojnosanitetski pregled · 1 jan 1999
The anatomical and functional status of the epifascial and subfascial lymphatic compartments was analyzed using two compartment lymphoscintigraphy in five groups of patients (total 55) with various forms of edema of the lower…
Two-compartment lymphoscintigraphy was developed to examine the sub- and epifascial lymphatics of the leg. Digital images were evaluated visually and semiquantitatively by calculating the uptake of activity within the lymph…
Bräutigam P et al. · Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 1 ago 1997
Twenty-four healthy subjects and 16 patients with lymphedema and lipedema were studied with MRI and ultratomography. In chronic lymphedema, ultrasonography revealed a statistically significant increase of the subcutaneous fat…
Dimakakos PB et al. · International surgery · 1 jan 1997
Lipoedema is a common but infrequently recognized condition causing bilateral enlargement of the legs in women. Although generally considered to be the result of an abnormal deposition of subcutaneous fat with associated oedema,…
Harwood CA et al. · The British journal of dermatology · 1 jan 1996
Early terms of lymphostasis in lipedema can be detected with lymphoscintigraphy. A normal examination almost certainly excludes a lymphatic component. Indirect lymphography is only used to rule out morphological abnormalities of…
Weissleder H et al. · Zeitschrift fur Lymphologie. Journal of lymphology · 1 dez 1995
Lymphoscintigraphy has emerged as the diagnostic test of choice in patients with suspected lymphedema. To assess the lymphatic circulation of 386 extremities in 188 patients, we prospectively recorded a semiquantitative index of…
Cambria RA et al. · Journal of vascular surgery · 1 nov 1993
Edemas of the leg sometimes pose problems for diagnosis. Invasive procedures like lymphography or phlebography are either difficult to perform or might endanger the lymphatics. The value of magnetic resonance imaging was assessed…
Werner GT, Rodiek SO · Zeitschrift fur Lymphologie. Journal of lymphology · 1 ago 1993
The authors assessed the use of magnetic resonance imaging in differentiating lymphedema, phlebedema, and lipedema of the lower limb. They examined 14 patients: five with lipedema, five with lymphedema, and four with phlebedema.…
An overall view of the clinical findings in lipedema is given and of its treatment. Lipedema is shown to be a distinct illness, and not just a disturbance of the distribution pattern of subcutaneous fatty tissue. The diagnosis is…
Wienert V, Leeman S · Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 1 ago 1991
The use of a single axial slice through the mid calf in the differential diagnosis of a swollen leg is described. This is a very simple quick non-invasive investigation. Venous obstruction results in an increase in the cross…
Lipedema is a common disease in the usual clinical practice. None organic description about the clinical symptoms and signs associated to this condition has been published. Fifty women with lipedema have been examined by the…
Bilancini S, Lucchi M, Tucci S · Angiologia · 1 jan 1990
Leg swelling is often of edematous nature. The most important differential diagnosis lies in the distinction between venous or lymphatic forms of edema. An increased vascular permeability and alterations in blood composition have…
Ludwig M, Vetter H · Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis · 12 set 1989
Lipedema is a hereditary disease concerning exclusively women. We discuss the characteristics of diagnosis as well as the differential diagnosis between lipedema and primary lymphedema. Therapy is effective if the lipedema…
Schmitz R · Zeitschrift fur Hautkrankheiten · 15 jan 1987
Twelve patients with primary lymphedema of the lower limb were examined with computed tomography (CT). A characteristic "honeycomb" pattern of the subcutaneous compartment was seen in 10 of these patients. CT scans in nine other…
Hadjis NS et al. · AJR. American journal of roentgenology · 1 fev 1985
Systemic causes of leg edema include idiopathic cyclic edema, heart failure, cirrhosis, nephrosis and other hypoproteinemic states. Lymphedema may be primary, or secondary to neoplasm, lymphangitis, retroperitoneal fibrosis and,…