Cada edição reúne o que entrou no PubMed naquela semana, com a evidência mais forte primeiro. Últimas 16 semanas.
6 artigos · Conservador, Diagnóstico, Epidemiologia
BackgroundLipedema is a chronic pain disorder characterized by disproportionate adipose tissue accumulation and pain of the affected extremities. While medical compression therapy is recommended for pain reduction, evidence…
Mendoza E · Phlebology · 30 out 2026
ObjectivesLipedema is a progressive adipose disorder affecting women, with diagnosis often delayed due to symptom overlap and lack of validated tools. This study assesses the Turkish version of the Lipedema Screening…
Ergin C et al. · Phlebology · 30 out 2026
Lipoedema and familial partial lipodystrophy (FPLD) are rare adipose tissue disorders frequently misclassified as common obesity. Clinical assessment and body mass index (BMI) alone may fail to capture regional fat distribution,…
Avci F et al. · Endocrine · 29 out 2026
BackgroundLipedema is a chronic adipofascial disorder characterized by pain, edema and progressive functional impairment. Conservative treatment is widely recommended as first-line therapy, but evidence on its impact on…
Fernandes B et al. · Phlebology · 29 out 2026
Pain and reduced mobility are common among people living with lipoedema. While well-fitting compression garments can help alleviate these symptoms, poorly fitting garments may be ineffective and contribute to significant material…
Murden S, Welsh L, Macintyre L · British journal of community nursing · 26 out 2026
BackgroundLipedema is a chronic condition that is increasingly being detected and gaining public awareness; however, strongly validated therapeutic options are lacking.ObjectivesGiven need for appropriate lipedema management…
Durmus H et al. · Phlebology · 26 out 2026
4 artigos · Diagnóstico, Epidemiologia, Cirurgia
BackgroundChronic venous disorders and lipedema are complex and frequently underdiagnosed conditions characterized by heterogeneous clinical presentations, progressive tissue remodeling, and substantial variability in treatment…
Hendesi F, Nazem A · Phlebology · 23 out 2026
To evaluate which factors are associated with change in lymphedema-specific quality of life (QoL) and relative volume difference in the maintenance phase after a multidisciplinary intensive treatment program in patients with…
Heroes A et al. · Lymphatic research and biology · 22 out 2026
IntroductionLipedema is a chronic adipose and connective tissue disorder in which pain is classically localized to affected limb tissue. However, some patients report joint, periarticular, myotendinous, or axial pain, with…
Fiengo E, Sbarbati A · Phlebology · 24 out 2026
This Letter to the Editor documents several verifiable internal inconsistencies in the article by Bruno and D'Antimi, including contradictory statements on study design, a level-of-evidence rating incompatible with the stated…
Amato ACM · Aesthetic plastic surgery · 19 out 2026
7 artigos · Diagnóstico, Fisiopatologia, Qualidade de vida, Cirurgia, Conservador
ObjectivesTo investigate the clinical and ultrasonographic changes associated with radial extracorporeal shock wave therapy (rESWT) in women with lipedema.MethodsThis prospective, single-arm study included 40 women with lipedema…
Özyiğit E et al. · Phlebology · 16 out 2026
ObjectivesLipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, lower extremity pain, functional impairment, and reduced quality of life. Although pain is a cardinal symptom, its…
Şahingöz Bakırcı E, Demir Karakılıç G · Phlebology · 16 out 2026
The aim of this study was to characterize global scientific output on lipedema from 2000 to 2025 and identify emerging thematic trends, with emphasis on the emergence of immunological research. Publications indexed in Google…
Amato ACM, Amato JLS, Benitti DA · Revista da Associacao Medica Brasileira (1992) · 16 out 2026
ObjectiveThis study aimed to comparatively evaluate sleep quality in individuals with lipedema and healthy controls. In addition, the relationships between sleep quality and depression, anxiety, fatigue, and clinical parameters…
Kesiktaş N, Ersoy S, Şirin Ahısha B · Phlebology · 15 out 2026
ObjectivesTo determine the prevalence of chronic venous insufficiency (CVI) in patients with lipedema, characterize venous reflux patterns and CEAP clinical classes, and evaluate associations with demographic and lipedema-related…
Gümrük Aslan S, Akın Yavuzel A, Gündoğdu O · Phlebology · 15 out 2026
Lipedema is a chronic disorder of adipose tissue marked by disproportionate fat accumulation in the extremities and persistent pain, which significantly impairs quality of life. Although liposuction has been adopted as a…
Halawani IR et al. · Aesthetic plastic surgery · 12 out 2026
BackgroundLipedema is a chronic condition that predominantly affects women and is commonly associated with pain, edema, and functional impairment. Conservative physiotherapy interventions are frequently recommended; however, the…
Rotili BC et al. · Phlebology · 18 out 2026
7 artigos · Diagnóstico, Fisiopatologia, Nutrição
There are no validated Norwegian disease-specific patient-reported outcome measures (PROMs) assessing quality of life (QoL) in females with lipedema, limiting evaluation of treatment effect in clinical practice and research. To…
Lundanes J et al. · Frontiers in global women's health · 9 out 2026
ObjectivesThis study aimed to determine the frequency of probable lipedema among women with lower extremity pain (LEP) using a validated screening questionnaire and to examine its associations with neuropathic pain (NP)…
Demir Karakılıç G et al. · Phlebology · 8 out 2026
Lipedema is a chronic adipose tissue disorder characterized by a disproportionate accumulation of painful subcutaneous fat on the extremities. Manual lymphatic drainage (MLD) is routinely used as therapeutic intervention, but its…
Nöll E et al. · Frontiers in cell and developmental biology · 7 out 2026
Lipedema is a chronic, predominantly female disorder characterized by disproportionate regional expansion of subcutaneous adipose tissue, pain, tenderness, and easy bruising. Reported abnormalities involve adipocytes,…
Faulhaber J et al. · Cells · 7 out 2026
Aim: This narrative review summarises evidence on pathogenetic mechanisms of adipose tissue remodelling and adipokine dysregulation in lipedema, focusing on adipocyte hypertrophy and hyperplasia, fibrosis, microcirculatory and…
Sierawska O, Dudzińska W · Current issues in molecular biology · 7 out 2026
Lipedema is a chronic adipose tissue disorder that predominantly affects women, although some rare cases do occur in men. We report the case of a 32-year-old man with symmetrical, lower-limb fat accumulation, foot sparing, pain,…
Kaefer M et al. · Jornal vascular brasileiro · 9 out 2026
Sem abstract disponível no PubMed.
Litaiem N, Slouma M · International journal of dermatology · 7 out 2026
6 artigos · Qualidade de vida, Fisiopatologia, Nutrição, Epidemiologia
Background/Objectives: Lipedema is an adipose tissue disorder associated with body-related burden. This study compared orthorexic eating tendencies between women with and without lipedema and examined associations with body-shape…
Doran M, Zincirci DE, Şahan EG · Journal of clinical medicine · 4 out 2026
The aim of this study was to compare serum adiponectin, leptin, resistin, irisin, and galectin-3 levels between patients with lipedema and healthy controls, and to examine their relationship with subcutaneous adipose tissue…
Şahingöz Bakırcı E, Demir Karakılıç G, Kaymak E · Aesthetic plastic surgery · 28 set 2026
Lipoedema is a painful adipose tissue disorder marked by disproportionate limb fat and often misclassified as generalized obesity or lymphoedema. This review examines its metabolic phenotype and implications for cardiometabolic…
Varghese RT, Varghese DG · Clinical obesity · 1 out 2026
A progressive disease, lipedema is characterized by bilaterally symmetrical and disproportional accumulation of subcutaneous adipose tissue (SAT) in the extremities, leading to severe pain, inflammation, and mobility issues.…
Gohlke S et al. · Frontiers in cell and developmental biology · 1 out 2026
Sem abstract disponível no PubMed.
Kemer S et al. · Journal of rehabilitation medicine · 2 out 2026
Sem abstract disponível no PubMed.
Mühlberg KS · MMW Fortschritte der Medizin · 1 out 2026
6 artigos · Qualidade de vida, Fisiopatologia, Nutrição, Diagnóstico, Cirurgia
To compare the efficacies of extracorporeal shock wave therapy (ESWT) and complex decongestive therapy (CDT) in patients with lipedema. This randomized-controlled-study included 33 patients with lipedema, with 11 patients in each…
Türköz MD, Kasap Z, Keleş B · American journal of physical medicine & rehabilitation · 24 set 2026
The clinical course of lipedema in women receiving hormonal treatment for concomitant estrogen-dependent gynecological disorders remains insufficiently characterized. This study aimed to describe gynecological and…
Frederichi de Souza P · Cureus · 24 set 2026
BackgroundLipedema is a frequently misdiagnosed chronic condition that significantly impacts patients' quality of life. As artificial intelligence (AI)-based large language models (LLMs) become increasingly integrated into…
Sanır R et al. · Phlebology · 23 set 2026
This study aimed to compare 12-week changes in body composition and anthropometric parameters between standard-dose and lower-dose tirzepatide escalation regimens in women with lipedema, with particular emphasis on changes in fat…
Frederichi de Souza P, Patriani G, Ribeiro Pacheco CM · Cureus · 23 set 2026
IntroductionAfter unification of diagnostic criteria for lipedema through guidelines and consensus documents as a fat-disproportion between abdomen and extremities with pain in the affected area, reduced by compression, expensive…
Mendoza E, Amsler F · Phlebology · 21 set 2026
A previously healthy 35-year-old woman developed recurrent syncope and dyspnoea two days after extensive thigh liposuction for lipedema. CT pulmonary angiography revealed a large saddle embolus with peripheral emboli. Fat…
Muhammad MGF et al. · Ugeskrift for laeger · 21 set 2026
2 artigos · Qualidade de vida, Nutrição
Individuals with lipoedema may experience negative impacts that are not often identified through current quality-of-life measures. The aim of this study was to explore the experiences of individuals living with pre-existing…
Stellmaker R et al. · International journal of qualitative studies on health and well-being · 18 set 2026
Low-carbohydrate diets (LCDs) have been suggested as a potential treatment option for females with lipedema, due to their superiority in reducing pain, possibly through improvements in insulin dynamics. The objective of this…
Lundanes J et al. · Frontiers in cell and developmental biology · 15 set 2026
5 artigos · Diagnóstico, Cirurgia, Fisiopatologia
To comprehensively characterize pain in women with lipedema and evaluate its relationship with central sensitization, neuropathic pain characteristics, pain sensitivity, sleep quality, and quality of life. : A cross-sectional…
Orhan B et al. · Pain medicine (Malden, Mass.) · 12 set 2026
The aesthetic-functional planning of the lower limbs is frequently conducted empirically, using idiosyncratic markings and limited standardization among specialists who work in this field. The absence of a common topographic…
Zeilmann E, Mello Netto BAS, Santos GS · Cureus · 12 set 2026
Lipedema is a chronic adipose tissue disorder that may involve the upper extremities, particularly in advanced disease stages, leading to pain, heaviness, and functional complaints. While liposuction is an established treatment…
Bruno A, Foti R · Aesthetic plastic surgery · 10 set 2026
This cross-sectional and descriptive study was conducted with 395 women to assess lipedema awareness, lipedema symptom levels, and the screening probability of lipedema. Data were collected using an Introduction Form, and the…
Şimşekli D, Yağcı Karamanlı H, Doğan C · Health care for women international · 8 set 2026
The Questionário de avaliação sintomática do lipedema (QuASiL - Lipedema Symptom Assessment Questionnaire) assesses 13 distinct inflammatory symptoms of lipedema, but whether these symptoms resolve and recur simultaneously or…
Amato ACM, Amato JLS, Benitti DA · Jornal vascular brasileiro · 7 set 2026
7 artigos · Cirurgia, Diagnóstico, Fisiopatologia
Lipoedema is a painful, chronic disease of the subcutaneous adipose tissue, predominantly affecting women. Conservative complex decongestive therapy is the standard of care but offers limited symptom relief. Liposuction appears…
Podda M et al. · Lancet (London, England) · 5 set 2026
Lipedema is a chronic progressive condition affecting approximately 10% of women, characterized by disproportionate subcutaneous adipose tissue accumulation and pain in the lower extremities. Standardized assessment methods for…
Patton L et al. · Life (Basel, Switzerland) · 2 set 2026
Lipedema is a common, female-predominant disorder characterized by disproportionate, painful lower-limb adipose tissue, and it still lacks an objective biomarker, a disease-modifying therapy, or consensus on whether its core…
Amato AC, Amato JL, Benitti D · Cureus · 1 set 2026
Lipedema is a chronic adipose tissue disorder characterized by bilateral and symmetrical subcutaneous fat accumulation, predominantly affecting women. Because it is frequently confused with obesity and lymphedema, diagnosis may…
Yukselmis O et al. · Frontiers in medicine · 31 ago 2026
Lipedema is a chronic, progressive, and often underdiagnosed disease characterized by the pathological, bilateral, and symmetrical accumulation of adipose tissue. This distribution results in disproportionate and painful swelling…
Nemes A · Reviews in cardiovascular medicine · 3 set 2026
Lipedema and obesity are often misdiagnosed or clinically confused yet arise via distinct mechanisms, complicating diagnosis and treatment. This review synthesizes evidence differentiating these conditions across genetic,…
Güney YE, Demiralay SÇ, Keser İ · Current issues in molecular biology · 1 set 2026
Sem abstract disponível no PubMed.
Brenner E, Bonomini F · Lancet (London, England) · 5 set 2026
1 artigo · Epidemiologia
Sem abstract disponível no PubMed.
Vaquero-Ramiro E, Puentes-Gutiérrez AB · Phlebology · 24 ago 2026
5 artigos · Diagnóstico, Epidemiologia
ObjectiveThis study aimed to investigate central sensitization (CS) in individuals with lipedema using pressure pain threshold measurements and to examine its relationship with clinical features, sonographic findings, body…
Yücel FN, Candan Z, Ata E · Phlebology · 18 ago 2026
Lipedema and obesity are chronic, frequently progressive disorders that can present with increased adipose-tissue volume, functional impairment and reduced quality of life. Although often approached as differential diagnoses,…
Scherkamp D et al. · Adipocyte · 20 ago 2026
Lower extremity swelling has a broad differential diagnosis, including lymphedema, obesity-induced lymphedema, phlebolymphedema, and lipedema. Although these conditions may appear similar clinically, their pathophysiology and…
Oh S et al. · Journal of clinical imaging science · 19 ago 2026
Hyperechoic subcutaneous nodules in lipedema may mimic angiolipomas but represent an inflammatory and hypoxic-ischemic process rather than a neoplasia, despite tissue expansion. As the painful nodules expand, biopsy is…
Vargas D et al. · Cureus · 19 ago 2026
Sem abstract disponível no PubMed.
Reyes Valdivia A et al. · Phlebology · 23 ago 2026
4 artigos · Qualidade de vida, Nutrição, Diagnóstico
Women with lipedema have an abnormal accumulation of adipose tissue that leads to pain and reduced quality of life (QoL). The impact of lipedema on body image and QoL remains largely unknown. The aim of this study is to explore…
Goodrose-Flores C, Björkhem-Bergman L · PloS one · 14 ago 2026
Lipedema is a chronic medical condition primarily affecting women, characterized by bilateral, symmetrical, disproportionate fat deposition in the lower limbs, and sometimes arms and lower trunk. Pharmacological interventions…
Srinivasan A et al. · Obesity pillars · 14 ago 2026
To evaluate ultrasonographic changes in lower extremity tendons and plantar fascia of patients with chronic edema and their relationship with edema volume, pain, function, and quality of life. This observational case-control…
Uğur AE, Soyupek F, Özçakar L · American journal of physical medicine & rehabilitation · 11 ago 2026
Lipedema is a chronic disorder characterized by excessive, bilateral, and symmetrical deposition of subcutaneous adipose tissue, predominantly in the lower extremities. Despite its prevalence, lipedema is frequently misdiagnosed…
Mortada H et al. · Plastic and reconstructive surgery. Global open · 10 ago 2026
2 artigos · Nutrição, Diagnóstico
Lipedema, a chronic condition primarily affecting women, is characterized by abnormal subcutaneous fat accumulation and swelling in the extremities (while sparing the hands, feet, and trunk). This disease is associated with…
Atabilen Pınar B et al. · Nutrition reviews · 1 ago 2026
Lipedema is a chronic progressive disease characterized by disproportionate and symmetric adipose tissue accumulation, predominantly affecting women, with upper extremity involvement (Type IV) in approximately 30% of cases. This…
Barros FS et al. · Phlebology · 29 jul 2026
5 artigos · Diagnóstico, Fisiopatologia, Conservador, Cirurgia
We aimed to evaluate the association between pain, body mass index (BMI), clinical stage, and morphological type in women with lipedema, using segmental bioimpedance to correlate with clinical symptoms. We conducted a…
Pusic J, Mora S, Froes Meyer P · Journal of vascular surgery. Venous and lymphatic disorders · 24 jul 2026
Lipedema is a chronic disorder of subcutaneous adipose tissue characterized by disproportionate fat accumulation, pain, and progressive functional impairment, predominantly affecting women. Research remains fragmented across…
Viana DPdC, Invitti AL, Schor E · Frontiers in cell and developmental biology · 22 jul 2026
Lipedema is a chronic disorder characterized by a disproportionate accumulation of subcutaneous adipose tissue in the extremities, typically sparing the hands and feet. It is commonly associated with pain, hypersensitivity, easy…
Modena DAO, Baiocchi JMT, Guirro ECdO · Jornal vascular brasileiro · 21 jul 2026
Lipedema is a chronic inflammatory disorder of adipose tissue that predominantly affects women and is characterized by disproportionate subcutaneous fat accumulation, pain, spontaneous bruising, and significantly impaired quality…
Lima MF · Jornal vascular brasileiro · 20 jul 2026
We read with great interest the article on Tranexamic acid use in Liposuction for Lipedema by Bruno and Foti [1]. Evaluating how tranexamic acid affected surgical results and expected blood loss in patients undergoing liposuction…
Qayyum A, Fatima F, Azeem L · Aesthetic plastic surgery · 22 jul 2026
1 artigo · Epidemiologia
Cashew nut allergy is increasing globally and may cause cross-allergic reactions to seed kernels from botanically related plants, including citrus. A woman in her twenties with a known nut allergy developed anaphylaxis after…
Kahrs GE, Lied GA · Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke · 14 jul 2026
3 artigos · Fisiopatologia, Epidemiologia
Lipedema is a chronic disorder that predominantly affects women and is characterized by abnormal subcutaneous adipose tissue accumulation, pain, and vascular dysfunction. However, reliable circulating biomarkers that reflect…
Kempa S et al. · Diseases (Basel, Switzerland) · 12 jul 2026
ObjectivesThe aim of this study was to compare metabolic status and biochemical indices associated with cardiovascular risk, including the triglyceride-glucose (TyG) index, triglyceride-glucose-body mass index (TyG-BMI), and…
Şirin Ahısha B et al. · Phlebology · 10 jul 2026
Sem abstract disponível no PubMed.
Simarro JL · International journal of obesity (2005) · 11 jul 2026