Background/Objectives: Non-invasive radiofrequency (NIRF) therapy is increasingly used in physical rehabilitation. However, its efficacy across different lower limb pathologies remains unclear. This study aimed to evaluate the…
Vinolo-Gil MJ et al. · Journal of clinical medicine · 22 mar 2026
Lipedema is a chronic, underdiagnosed adipose disorder marked by disproportionate fat accumulation, pain, and impaired mobility. Misdiagnosis as obesity or lymphedema delays care and increases morbidity. We systematically…
Vazirnia A et al. · International journal of dermatology · 7 jan 2026
Lipedema is a chronic disease characterized by the disproportionate and symptomatic accumulation of fat in the lower limbs and arms. Women with lipedema experience heaviness, fatigue and pain, leading to impairments in daily…
Lanzi S et al. · VASA. Zeitschrift fur Gefasskrankheiten · 17 nov 2025
Objectives: This study aimed to examine the effects of a multimodal exercise program on edema, pain, exercise capacity, lower extremity muscle strength, and function in patients with lipedema.Methods: The patients diagnosed with…
To summarize the evidence of the immediate and long-term effect of exercise interventions in patients with either primary or secondary lower limb lymphedema (LLL) on health-related quality of life (HR-QOL), physical function,…
Wittenkamp MC et al. · Acta oncologica (Stockholm, Sweden) · 31 mar 2025
Does short-term use of pneumatic compression devices (PCD) and off-the-shelf compression alleviate symptoms and improve quality of life in women with lipedema and secondary lipolymphedema? Prospective, randomized controlled,…
BackgroundLipedema is a chronic pain disorder characterized by disproportionate adipose tissue accumulation and pain of the affected extremities. While medical compression therapy is recommended for pain reduction, evidence…
BackgroundLipedema is a chronic adipofascial disorder characterized by pain, edema and progressive functional impairment. Conservative treatment is widely recommended as first-line therapy, but evidence on its impact on…
BackgroundLipedema is a chronic condition that is increasingly being detected and gaining public awareness; however, strongly validated therapeutic options are lacking.ObjectivesGiven need for appropriate lipedema management…
Pain and reduced mobility are common among people living with lipoedema. While well-fitting compression garments can help alleviate these symptoms, poorly fitting garments may be ineffective and contribute to significant material…
Murden S, Welsh L, Macintyre L · British journal of community nursing · 26 out 2026
BackgroundLipedema is a chronic condition that predominantly affects women and is commonly associated with pain, edema, and functional impairment. Conservative physiotherapy interventions are frequently recommended; however, the…
Lipedema is a chronic disorder characterized by a disproportionate accumulation of subcutaneous adipose tissue in the extremities, typically sparing the hands and feet. It is commonly associated with pain, hypersensitivity, easy…
Background/Objectives: Non-invasive radiofrequency (NIRF) therapy is increasingly used in physical rehabilitation. However, its efficacy across different lower limb pathologies remains unclear. This study aimed to evaluate the…
Vinolo-Gil MJ et al. · Journal of clinical medicine · 22 mar 2026
Lipedema is a chronic condition characterized by abnormal subcutaneous fat accumulation, predominantly affecting women. It is associated with pain, swelling, reduced mobility, and psychological distress, all of which may limit…
Åström Malm I, Violasdotter Nilsson P, Hurtig-Wennlöf A · BMC women's health · 15 jan 2026
Lipedema is a chronic, underdiagnosed adipose disorder marked by disproportionate fat accumulation, pain, and impaired mobility. Misdiagnosis as obesity or lymphedema delays care and increases morbidity. We systematically…
Vazirnia A et al. · International journal of dermatology · 7 jan 2026
IntroductionCompression pressure is the key factor determining effectiveness in compression therapy for venous and lymphatic disorders. Despite its clinical importance, few studies report the actual applied pressure, and national…
Lipedema is an abnormal accumulation of subcutaneous fat that usually affects the lower extremities. Inflammation due to adipose tissue may negatively affect body structure and functions. This case-control study aimed to assess…
Haspolat M et al. · Physiotherapy theory and practice · 28 nov 2025
Lipedema is a chronic disease characterized by the disproportionate and symptomatic accumulation of fat in the lower limbs and arms. Women with lipedema experience heaviness, fatigue and pain, leading to impairments in daily…
Lanzi S et al. · VASA. Zeitschrift fur Gefasskrankheiten · 17 nov 2025
BackgroundCompression therapy (CT) is widely prescribed for chronic venous disease (CVD), lymphedema, and lipedema despite robust evidence supporting its effectiveness only in a minority of clinical scenarios.AimProvide an…
Objectives: This study aimed to examine the effects of a multimodal exercise program on edema, pain, exercise capacity, lower extremity muscle strength, and function in patients with lipedema.Methods: The patients diagnosed with…
Lipedema is a painful disease of subcutaneous adipose tissue (SAT) in women. This study determined whether an advanced pneumatic compression device (APCD) improved lipedema SAT depth, swelling, and pain. Women with lipedema…
Herbst KL et al. · Life (Basel, Switzerland) · 30 abr 2025
To summarize the evidence of the immediate and long-term effect of exercise interventions in patients with either primary or secondary lower limb lymphedema (LLL) on health-related quality of life (HR-QOL), physical function,…
Wittenkamp MC et al. · Acta oncologica (Stockholm, Sweden) · 31 mar 2025
Background: Lipedema is an adipose tissue disorder in women, with an abnormal fat deposition in lower limbs and occasionally upper limbs. The condition is characterized by pain, bruising, heaviness, and mobility impairment.…
Río-González Á et al. · Journal of clinical medicine · 21 mar 2025
The treatment of lipedema remains challenging, largely due to widespread misconceptions. Selecting the appropriate treatment method necessitates the use of accurate outcome measures. This study aims to evaluate the effectiveness…
Czerwińska M et al. · Life (Basel, Switzerland) · 22 out 2024
Background: Lipedema is a disease characterized by an increase in extracellular fluid. In these patients, the increase in the amount of extracellular fluid may accelerate the progression of the disease. The aim of this study is…
Esmer M, Schingale FJ · Lymphatic research and biology · 9 out 2024
We evaluated the effect of compression leggings with micromassage in association with physical activity on women with lipedema, not previously treated and without recent changes in body weight. The treatment resulted in an…
Ricolfi L et al. · Life (Basel, Switzerland) · 8 jul 2024
This consensus statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF) provides the…
Annunziata G et al. · Current obesity reports · 3 jul 2024
Background: Complex decongestive therapy (CDT) is the standard and basic therapy for lymphedema. The central component of CDT is manual lymphatic drainage (MLD). In addition to CDT, other measures such as intermittent pneumatic…
Schiltz D et al. · Journal of clinical medicine · 23 fev 2024
National survey data exploring the patient experience with lipedema are lacking. We conducted national surveys from 2016 to 2022 of women with lipedema as well as female controls. Surveys collected information on symptomatology,…
Aday AW et al. · Vascular medicine (London, England) · 16 out 2023
(1) Background: Although lipedema has gained more interest among researchers, specific treatment methods are still unknown. This study aims to identify the effects of compression therapy combined with exercises compared to…
Czerwińska M et al. · International journal of environmental research and public health · 4 jan 2023
Does short-term use of pneumatic compression devices (PCD) and off-the-shelf compression alleviate symptoms and improve quality of life in women with lipedema and secondary lipolymphedema? Prospective, randomized controlled,…
Lipoedema is a chronic feminine disease with disproportional painful fat deposition of the lower body half and occassional arm affection. The objective of the present study was to assess LA volumetric and functional properties by…
Nemes A et al. · Postepy dermatologii i alergologii · 14 jul 2022
(1) Background: Due to insufficient knowledge of lipoedema, the treatment of this disease is undoubtedly challenging. However, more and more researchers attempt to incorporate the most effective lipoedema treatment methods. When…
Czerwińska M, Teodorczyk J, Hansdorfer-Korzon R · International journal of environmental research and public health · 10 jun 2022
Background: Lipedema is a distinct adipose disorder from obesity necessitating awareness as well as different management approaches to address pain and optimize quality of life (QoL). The purpose of this proof-of-principle study…
Donahue PMC et al. · Lymphatic research and biology · 8 nov 2021
Lipedema is a chronic feminine disease that causes abnormal fat deposition in lower limbs and occasionally upper limbs. Easy bruising and pain are common. Lipedema patients suffer from both physical and psychological disability.…
Forner-Cordero I, Forner-Cordero A, Szolnoky G · International angiology : a journal of the International Union of Angiology · 19 abr 2021
Objective: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on upper extremity circumference and volume in patients with…
Volkan-Yazici M, Esmer M · Lymphatic research and biology · 5 abr 2021
Background: Lack of diagnostic awareness of lipedema and frequent confusion with obesity or lymphedema may be an obstacle for treatment. The clinical effects of conservative treatment methods are not clearly known. This study…
Atan T, Bahar-Özdemir Y · Lymphatic research and biology · 9 dez 2020
Background: The aim of this study is to investigate the effect of complex decongestive physiotherapy (CDP) plus intermittent pneumatic compression (IPC) applications on lower extremity limb circumference and volume in patients…
Volkan-Yazıcı M, Yazici G, Esmer M · Lymphatic research and biology · 30 out 2020
Compression hosiery is commonly used for the management of lymphoedema as well as lipoedema, but it is more commonly indicated for the lower limbs than for the upper limbs. The effects of compression hosiery on upper-limb…
Elwell R, Rich A · British journal of community nursing · 1 out 2020
The COVID-19 pandemic poses a challenge to the management of non-COVID pathologies such as lymphatic diseases and lipoedema. The use of telemedicine can prevent the spread of the disease. A system is needed to help determine the…
Forner Cordero I et al. · Rehabilitacion · 8 ago 2020
Lipedema is a lymphedema-masquerading symmetrical, bilateral and disproportional obesity. Its conservative maintenance treatment comprises the use of flat-knitted compression pantyhoses. Lipedema is known to be associated with…
Lipedema is a chronic, common but underdiagnosed disease masquerading obesity, with female predominance, characterized by disproportional abnormal adipose tissue distribution of the lower and also upper extremities. The present…
Nemes A et al. · Journal of clinical ultrasound : JCU · 11 mai 2020
Lipoedema is an incurable chronic disease causing limb deformity, painful skin and excessive ecchymosis. Compression garments are frequently recommended to manage symptoms, but the existing products are not designed specifically…
Paling I, Macintyre L · British journal of community nursing · 1 abr 2020
Compression therapy is the mainstay of treatment in venous and lymphatic diseases. Optimisation of compression therapy is not a new concept, but, in the UK, the use of 24-hour compression therapy as part of the maintenance phase…
Phillips N, Lawrance S · British journal of community nursing · 1 abr 2020
Lipoedema, an adipose tissue disorder, is a poorly visible, often unrecognised condition. To foster a greater understanding of the significant and debilitating impacts faced by women living with lipoedema, the charity Lipoedema…
Fetzer A · British journal of community nursing · 1 abr 2020
Chronic oedema is a term that encompasses several causes that lead to oedema formation in any part of the body. This includes lymphoedema and its subcategories. Despite the assumption that these are different, there are more…
Cooper-Stanton G · British journal of community nursing · 1 abr 2020
Lipedema is a chronic and progressive disease of adipose tissue caused by abnormal fat accumulation in subcutaneous tissue. Although there is no known cure for lipedema, possible complications can be prevented with conservative…
Lipedema is a barely recognized and poorly diagnosed, but common disease affecting almost exclusively female patients. The pathomechanism of lipedema is not known, and clinically, it is a bilateral, symmetrical, disproportional…
Nemes A et al. · Echocardiography (Mount Kisco, N.Y.) · 18 jul 2019
In case of an acute leg swelling a deep leg vein thrombosis needs to be excluded. In order to do this, compression sonography and the D-dimer-test are applied in the framework of an established diagnostic algorithm. The ensuing…
Präve F, Hoffmann K · Deutsche medizinische Wochenschrift (1946) · 14 mar 2019
Under the direction of the German Society of Phlebology (Deutsche Gesellschaft für Phlebologie) and in cooperation with other specialist associations, the S1 guideline on intermittent pneumatic compression (IPC) was adopted in…
Schwahn-Schreiber C et al. · Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 1 ago 2018
Purpose: Although the exact prevalence of lipedema is unknown the number of women suffering from this condition is ever-growing. When treated conservatively, manual lymphatic drainage is regarded the gold standard. However, the…
Schneider R · Physiotherapy theory and practice · 30 mai 2018
Lymphoedema results from a failure of the lymphatic system. The consequences are swelling, skin and tissue changes and predisposition to infection. Lipoedema, however, results from the predisposition of an excessive number of fat…
Elwell R, Heal D, Lister L · British journal of community nursing · 1 out 2017
Self-management and the use of adjustable velcro compression wraps are not new concepts and quite often both can form part of the maintenance phase of treatment in those with lymphoedema or lipoedema, as well as those diseases in…
Lee N, Pugh S, Cooper R · British journal of community nursing · 1 out 2017
The present, revised guidelines on lipedema were developed under the auspices of and funded by the German Society of Phlebology (DGP). The recommendations are based on a systematic literature search and the consensus of eight…
Reich-Schupke S et al. · Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 1 jul 2017
The use of velcro compression wrapping devices in the management of lymphoedema and chronic oedema is not a new concept. Wraps have been available for many years and are being used widely in clinic and community settings where…
Lee N, Lawrence S · British journal of community nursing · 1 mai 2017
Compression therapy is a key component in the effective management of people with lower limb problems associated with venous, lymphatic and fat disorders such as lipoedema. Individuals with lymphoedema, venous ulceration and…
While there is no proven cure for lipoedema, early detection is key as specialist treatments, complemented by self-management techniques, can improve symptoms and prevent progression. There is no universal approach as the correct…
Fetzer A · British journal of community nursing · 1 abr 2016
Selecting the most appropriate compression garments is vital in the long-term management of venous disease and chronic oedema. The range of styles has improved greatly over the years and many garments are available on the UK Drug…
Todd M, Elwell R, Pritchard E · British journal of community nursing · 1 abr 2016
At present, there is no proven cure for lipoedema. Nevertheless, much can be done to help improve symptoms and prevent progression. Many of these improvements can be achieved by patients using self-management techniques. This…
Fetzer A, Wise C · British journal of community nursing · 1 out 2015
Compression therapy is the mainstay of treatment in the management of lymphoedema and lipoedema. However, due to variance in the location, severity and type of the condition, patients often have to compromise on garments to…
Wigg J, Lee N · British journal of community nursing · 1 out 2014
The management of lymphoedema is complex and should be based on guidelines. To date, no data assessing quality of care in lymphoedema in Germany are available. We aimed at evaluating the quality of care of lymphoedema in the…
Herberger K et al. · Dermatology (Basel, Switzerland) · 2 jul 2013
The International Compression Club (ICC) is a partnership between academics, clinicians and industry focused upon understanding the role of compression in the management of different clinical conditions. The ICC meet regularly…
Flour M et al. · International wound journal · 21 jun 2012
Lymphedema and lipedema are chronic progressive disorders for which no causal therapy exists so far. Many general practitioners will rarely see these disorders with the consequence that diagnosis is often delayed. The…
Lipedema is a disproportional obesity featuring frequent hematoma formation due to even minor traumatic injuries. On the basis of clinical observations, complete decongestive physiotherapy diminishes the incidence of hematomas…
Lipedema is a disproportional obesity for which evidence-based treatment is not currently available. We studied whether complete decongestive physiotherapy (CDP) alone or combined with intermittent pneumatic compression (IPC)…
Lymphoedema is a clinical manifestation of an impaired lymphatic drainage with accumulation of lymphatic fluid. Lipoedema is characterized by bilateral enlargement of the legs and/or arms due to abnormal deposition of fatty…
After studying this article, the participant should be able to: 1. Discuss the initial evaluation of a patient presenting with lower extremity enlargement. 2. Distinguish underlying medical conditions causing lower extremity…
Warren AG et al. · Plastic and reconstructive surgery · 1 jan 2007
Leg edema is a common problem in the elderly and requires further evaluation and management. From October 1990 to July 1992, 245 patients presented to the Cleveland Clinic Florida with leg edema. All patients were counseled about…
Ciocon JO, Galindo-Ciocon D, Galindo DJ · Angiology · 1 jan 1995
Two cases of lipedema are presented. They illustrate this clinical syndrome which occurs almost exclusively in women and presents as grossly enlarged legs, thighs and buttocks. The etiology remains uncertain. Although…